Terminal arteriolar network structure/function and plasma cytokine levels in db/db and ob/ob mouse skeletal muscle.

Objective: To investigate the terminal arteriolar network structure and function in relation to circulating plasma cytokine levels in db/db, ob/ob, and their genetic background control, C57/bl6, mice.

Methods: Arteriolar network size and erythrocyte distribution were observed in the resting cremaster muscle (n = 45, pentobarbital 50 mg/kg i.p.

Segmental blood flow and rheological determinants in diabetic patients with peripheral occlusive arterial disease.

Vascular abnormalities are more prevalent in the lower extremities in diabetic patients and may cause diminished perfusion to surrounding tissues. We sought to identify blood flow abnormalities in the leg of diabetic patients with peripheral occlusive arterial disease (POAD) and to determine whether these were associated with abnormalities in rheological determinants, namely, plasma fibrinogen concentration (PFC), relative plasma viscosity (RPV), hematocrit (Hct), and whole blood viscosity (WBV). Seventeen diabetic patients with POAD were compared with 40 diabetic patients without POAD and 19 nondiabetic control subjects.

Glycaemic control influences peripheral blood flow and haemorheological variables in patients with diabetes mellitus.

Since persistent uncontrolled hyperglycaemia predisposes to vascular complications in diabetics, this study aimed at assessing the relationship of glycaemic control to plasma fibrinogen concentration, relative plasma viscosity and ankle arterial blood flow in diabetic patients with (N = 28) and without neuropathy (N = 34) compared with non-diabetic controls (N = 21). Glycaemic control was determined by total glycated haemoglobin (GHb) levels. Patients were placed into three categories of glycaemic control, namely good (GHb 4 -< 8%), fair (GHb 8-12%) and poor (GHb > 12%).

Venodynamic and hemorheological variables in patients with diabetes mellitus.

Background: The association between diabetes mellitus and the occurrence of peripheral vascular disease has been well established. However, it is unclear whether the venous circulation is also affected. This study was done to determine whether there is impairment of venous function in the legs of patients with diabetes mellitus and the relationship with rheological parameters.