Publications by authors named "Jacqueline Rowan"
Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand.
Harald Noedl Srivicha Krudsood Kobsiri Chalermratana Udomsak Silachamroon Wattana Leowattana Jacqueline Rowan
Clin Infect Dis
November 2006
Article Synopsis
- The study addresses the urgent need for new malaria treatments due to rising drug resistance, exploring azithromycin, a safe antibiotic for children and pregnant women, combined with artesunate and quinine.
- A 28-day clinical trial tested four different azithromycin-based treatment regimens on adult patients with uncomplicated malaria, aiming for 25 subjects per group.
- Results showed high cure rates (88.9% to 92%) in the azithromycin-artesunate groups, faster recovery times compared to quinine treatments, but some early treatment failures occurred, particularly with the azithromycin-quinine combination.