Publications by authors named "Jacqueline Nakel"
Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to infection and transformation. A fundamental difference in early viral gene expression between infection and MCPyV-driven tumorigenesis is the expression of a truncated LT (LTtr) in the tumor.
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- Drug-based antiretroviral therapies (ART) effectively control HIV replication but can't eliminate the virus since it remains as integrated proviral reservoirs in cells.
- Genome editing tools like the HIV-1 LTR-specific designer-recombinase Brec1 show promise in removing these integrated HIV genomes, indicating potential for curative therapies.
- A comprehensive preclinical study of Brec1 demonstrated it has minimal safety risks, including no harmful immune responses, making it a suitable candidate for future clinical trials aimed at eradicating HIV-1.
Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases.
View Article and Find Full Text PDFHabitat destruction and fragmentation are among the major current threats to global biodiversity. Fragmentation may also affect species with good dispersal abilities. We study the heath bushcricket , a specialist of steppe-like habitats across Europe that are highly fragmented, investigating if these isolated populations can be distinguished using population genomics and if there are any traces of admixture or dispersal among them.
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- * Focus is on Stenotrophomonas maltophilia, which forms harmful biofilms on medical devices, and how a supernatant from stony coral can reduce biofilm formation by 40%.
- * Researchers identified metalloproteases in the supernatant that contribute to the anti-biofilm effects, highlighting their potential as new antimicrobial agents in health care.
Background: Worldwide observations revealed increased frequencies of multi-resistant Enterobacterales and resistance genes in hospital wastewater compared to any other type of wastewater. Despite the description of clonal lineages possibly adapted to hospital wastewater, little is known about long term persistence as well as evolution of these lineages.
Methods: In this study, wastewater isolates of different Enterobacterales species from a tertiary care hospital were investigated with 2.
Background: As microRNA-142 (miR-142) is the only human microRNA gene where mutations have consistently been found in about 20% of all cases of diffuse large B-cell lymphoma (DLBCL), we wanted to determine the impact of miR-142 inactivation on protein expression of DLBCL cell lines.
Methods: miR-142 was deleted by CRISPR/Cas9 knockout in cell lines from DLBCL.
Results: By proteome analyses, miR-142 knockout resulted in a consistent up-regulation of 52 but also down-regulation of 41 proteins in GC-DLBCL lines BJAB and SUDHL4.
Article Synopsis
- NK cells are crucial for fighting viral infections and use a variety of receptors, with HLA-C being the main ligand for Killer-cell immunoglobulin-like receptors (KIRs), influencing NK cell activity.
- The study shows that HIV-1 can evade the immune response by adapting to host genetics, particularly through the Vpu protein that downregulates HLA-C, which helps the virus escape detection by NK cells.
- Researchers found that HIV-1 infection leads to changes in the NK cell receptor profile, including an increase in specific NK cell populations and a genotype-dependent expansion of KIR2DL1, indicating a complex relationship between the immune response and HIV-1 evolution.
Article Synopsis
- * The first outbreak involved a non-variant of concern strain linked to a superspreading event, while the second outbreak was caused by the Alpha variant (B.1.1.7), both originating from childcare workers, with children playing a significant role in transmitting the virus to households.
- * Results revealed that infections from B.1.1.7-infected children led to more frequent secondary transmissions than those from non-VOC infections, emphasizing the need for rigorous testing and contact screening in daycare centers to prevent further spread, especially with the