Stimulatory catfish leukocyte immune-type receptors (IpLITRs) demonstrate a unique ability to associate with adaptor signaling proteins and participate in the formation of homo- and heterodimers.

Channel catfish leukocyte immune-type receptors (IpLITRs) are immunoglobulin superfamily (IgSF) members believed to play a role in the control and coordination of cellular immune responses. Some IpLITR-types encode a transmembrane (TM) region containing a single positive charged lysine (K) residue, which is a key feature of stimulatory immune receptors that associate with immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor proteins. In this study we focused on identifying the signaling adaptor molecules recruited by putative stimulatory IpLITRs as a first step towards elucidating their ability to regulate catfish immune cell effector functions.

Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2.

Channel catfish leukocyte immune-type receptors (IpLITRs) are immunoglobulin superfamily (IgSF) members believed to play a role in the control and coordination of cellular immune responses in teleost. Putative stimulatory and inhibitory IpLITRs are co-expressed by different types of catfish immune cells (e.g.