Publications by authors named "Jacqueline Mathews"
Article Synopsis
- Metabolic phenotyping using molecular fingerprints shows promise for clinical diagnostics but faces challenges with data usability and workflow efficiency.* -
- MetaboScope is a comprehensive tool designed for analyzing H nuclear magnetic resonance data, featuring advanced statistical methods for data preprocessing and modeling.* -
- The MetaboScope system operates as a web app in JavaScript, allowing users to process data locally without uploads, and includes resources like tutorials and datasets for easy access and implementation.*
Diabetes mellitus is a central driver of multiple long-term conditions (MLTCs), but population-based studies have not clearly characterized the burden across the life course. We estimated the age of onset, years of life spent and loss associated with diabetes-related MLTCs among 46 million English adults. We found that morbidity patterns extend beyond classic diabetes complications and accelerate the onset of severe MLTCs by 20 years earlier in life in women and 15 years earlier in men.
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- The study aimed to evaluate the prevalence of multiple long-term conditions (MLTC) among the entire English population, considering factors such as age, sex, socioeconomic status, and ethnicity.
- Out of over 60 million registered individuals, the overall MLTC prevalence was found to be 14.8%, with significant variation across age groups—0.9% in those aged 0-19 and 68.2% in those aged 80 and over.
- Results indicated higher odds of MLTC among men, the most deprived socioeconomic groups, and those of Asian ethnicity, while lower odds were found for Black, mixed, and other ethnicities, with different prevalent conditions observed at various age ranges.
Diabetes mellitus is a complex metabolic disease characterised by glucose overproduction and under-utilisation. As the incidence of diabetes expands rapidly across the globe there is an urgent need to expand the range of effective treatments. Higher plants such as Asparagus adscendens provide therapeutic opportunities and a rich source of potential antidiabetic agents.
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