Missense Mutation Associated With Fatty Acid Metabolism and Reduced Height in Greenlanders.

Background: Inuit have lived for thousands of years in an extremely cold environment on a diet dominated by marine-derived fat. To investigate how this selective pressure has affected the genetic regulation of fatty acid metabolism, we assessed 233 serum metabolic phenotypes in a population-based sample of 1570 Greenlanders.

Methods And Results: Using array-based and targeted genotyping, we found that rs80356779, a p.