Publications by authors named "Jacqueline M Garonzik-Wang"
Background: Kidney transplant recipients (KTR) are at risk of severe coronavirus disease 2019 (COVID-19) disease and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We predicted that hospitalization for COVID-19 and subsequent admission to the intensive care unit (ICU) would yield worse outcomes in KTRs.
Aim: To investigate outcomes among KTRs hospitalized at our high-volume transplant center either on the general hospital floor or the ICU.
Background: Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2 mRNA vaccination among aSOTRs.
View Article and Find Full Text PDFOmicron Infections in Vaccinated Pediatric Solid Organ Transplant Recipients.
J Pediatric Infect Dis Soc
February 2024
Article Synopsis
- SARS-CoV-2 infections were common among vaccinated pediatric solid organ transplant recipients (pSOTRs) during the Omicron period, even with strong anti-RBD antibody responses.
- The findings indicate that while pSOTRs generated good antibody responses, these antibodies had limited effectiveness in neutralizing Omicron subvariants.
- Breakthrough infections in this group tended to be relatively mild in terms of severity.
Article Synopsis
- * A study of 1,406 ILDKT recipients revealed that older patients showed increased mortality risk (hazard ratio: 2.07) but similar rates of delayed graft function (DGF) and length of stay (LOS) compared to younger counterparts.
- * The effects of age on transplant outcomes were consistent across both ILDKT and compatible living donor kidney transplant (CLDKT) groups, suggesting that age should not disqualify older patients from receiving ILDKT.
Article Synopsis
- * Data from 2009 to 2020 revealed that candidates who accepted DCD liver offers had significantly better long-term survival rates than those who declined, with a 46% lower mortality risk after adjusting for various factors.
- * The findings suggest a strong case for promoting the acceptance and recovery of DCD livers, even those from older or higher-risk donors, to improve outcomes for liver transplant candidates.
Unlabelled: Incompatible living donor kidney transplant recipients (ILDKTr) require desensitization to facilitate transplantation, and this substantial upfront immunosuppression may result in serious complications, including cancer.
Methods: To characterize cancer risk in ILDKTr, we evaluated 858 ILDKTr and 12 239 compatible living donor kidney transplant recipients (CLDKTr) from a multicenter cohort with linkage to the US transplant registry and 33 cancer registries (1997-2016). Cancer incidence was compared using weighted Cox regression.
Article Synopsis
- A quality improvement initiative was implemented at a single academic center to standardize immediate postoperative extubation (IPE) practices for liver transplant recipients, aiming to increase IPE rates while including high-risk patients.
- A retrospective study of 591 liver transplant patients from 2013 to 2018 showed significant increases in IPE rates over time, especially among high-risk groups, with minimal reintubation rates and no effect on mortality.
- IPE was found to be linked with shorter intensive care unit and overall hospital lengths of stay, demonstrating the benefits of standardized care practices in liver transplant procedures.
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.
View Article and Find Full Text PDFBackground: Solid organ transplant recipients (SOTRs) are less likely to mount an antibody response to SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine response can guide strategies for antibody testing and additional vaccine dose recommendations.
Methods: Using a nationwide observational cohort of 1031 SOTRs, we created a machine learning model to explore, identify, rank, and quantify the association of 19 clinical factors with antibody responses to 2 doses of SARS-CoV-2 mRNA vaccines.
Unlabelled: Kidney transplantation (KT) is controversial in patients with pretransplant pulmonary hypertension (PtPH). We aimed to quantify post-KT graft and patient survival as well as survival benefit in recipients with PtPH.
Methods: Using UR Renal Data System (2000-2018), we studied 90 819 adult KT recipients.
Background: The allocation of scarce deceased donor kidneys is a complex process. Transplant providers are increasingly relying on constructs such as frailty and cognitive function to guide kidney transplant (KT) candidate selection. Patient views of the ethical issues surrounding the use of such constructs are unclear.
View Article and Find Full Text PDFHeterologous vaccination ("mixing platforms") for the third (D3) dose of SARS-CoV-2 vaccine is a potential strategy to improve antibody responses in solid organ transplant recipients (SOTRs), but data are mixed regarding potential differential immunogenicity. We assessed for differences in immunogenicity and tolerability of homologous (BNT162b2 or mRNA-1273; D3-mRNA) versus heterologous (Ad.26.
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