Publications by authors named "Jacqueline Lowdon"

Nutrition has played a central role in the management and outcomes of people with cystic fibrosis (pwCF) since the 1970s. Advances in therapies and practices in recent decades have led to a significant change in the patient landscape with dramatic improvements in life expectancy, as well as quality of life, bringing with it new issues. Historically, cystic fibrosis was a condition associated with childhood and malnutrition; however, changes in patient demographics, nutritional assessment and fundamental nutritional management have evolved, and it has become an increasingly prevalent adult disease with new nutritional challenges, including obesity.

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Article Synopsis
  • - This paper is part of a series updating standards of care for cystic fibrosis (CF), emphasizing the importance of recognizing and managing various CF health issues despite advancements like CFTR modulators.
  • - It highlights the need for multidisciplinary care to address ongoing extrapulmonary issues such as diabetes, liver disease, and increased cancer risk, which require regular screenings.
  • - Mental and emotional support is crucial for individuals with CF and their families, especially during challenging times, and planning for end-of-life care should be approached with sensitivity and compassion.
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Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transformed the management of CF. The latest standards of care from the European CF Society (2018) did not include guidance on variant-specific therapy, as CFTR modulators were becoming established as a novel therapy.

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Background: Enteral tube feeding is routinely used in many cystic fibrosis centres when oral dietary and supplement intake has failed to achieve an adequate nutritional status. The use of this method of feeding is assessed on an individual basis taking into consideration the patients age and clinical status. This is a final update of a previously published review.

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