Lopinavir-Ritonavir in the Treatment of COVID-19: A Dynamic Systematic Benefit-Risk Assessment.

Introduction And Objective: COVID-19 is an ongoing, global public health crisis for which safe and effective treatments need to be identified. The benefit-risk balance for the use of lopinavir-ritonavir in COVID-19 needs to be monitored on an ongoing basis, therefore a systematic benefit-risk assessment was designed and conducted. A key objective of this study was to provide a platform for a dynamic systematic benefit-risk evaluation; although initially this evaluation is likely to contain limited information, it is required because of the urgent unmet public need.

Use of fibre dressings in children with severe epidermolysis bullosa.

This non-comparative study explored the benefits of a natural gelling fibre dressing in 10 children with epidermolysis bullosa (EB). The clinical challenge in managing these children is that they often present with recalcitrant wounds that are perpetuated by critical colonisation, presence of biofilms and infection. KytoCel® (Aspen Medical) is a highly absorbent dressing composed of natural, biodegradable acylated chitosan.

Managing pain in children with epidermolysis bullosa.

Epidermolysis bullosa is a rare genetic skin fragility disorder, with several types of varying severity. While research is progressing towards effective treatments, management remains symptomatic. One of the most distressing symptoms is pain, which may be multifactorial in origin.

Reducing pain during the removal of adhesive and adherent products.

Silicone Medical Adhesive Removers (SMARs) have proved a valuable addition to formularies. In the absence of SMARs, trauma following removal of adhesive dressings, ostomy products, retention tapes and monitoring equipment can lead to skin stripping or extension of existing wounds. Those at increased risk of skin stripping include groups such as older people, premature infants and neonates and those with skin fragility syndromes.

Wound management for children with epidermolysis bullosa.

Skin and wound care in epidermolysis bullosa (EB) is specific both to the type of EB and to individual wounds within each child. Availability of dressings and personal preference are also paramount in the selection of materials. The ideal dressing is yet to be developed, although there are now a variety of suitable dressings available.

Letters.

ABPI: CORRECT TECHNIQUE ESSENTIAL MANAGING EPIDERMOLYSIS BULLOSA OCCLUSIVE DRESSINGS GIVE PAIN RELIEF CYCLE TIMES OF PRODUCTS USED FOR INTERMITTENT COMPRESSION TREATMENT.