Publications by authors named "Jacquelin Bui-Griffith"
Article Synopsis
- Radiation exposure may be linked to the development of medullary thyroid cancer, but no previous studies have examined its oncogenic events in affected populations.
- In this study, researchers analyzed tissue samples from 49 individuals affected by thyroid cancer post-Chernobyl, identifying various germline RET mutations and sporadic cancer cases with RET-related alterations.
- The findings indicate a notable prevalence of hereditary mutations and suggest that radiation exposure does not significantly impact tumor characteristics or age at diagnosis in sporadic cases.
Purpose: Anaplastic thyroid cancer (ATC) is a deadly form of thyroid cancer. V600E is the only actionable mutation for which there is a Food and Drug Administration-approved drug combination. Rapid detection of V600E and initiation of therapy is critical.
View Article and Find Full Text PDFMedullary thyroid carcinoma (MTC), an aggressive form of thyroid cancer, occurs sporadically in approximately 75% of MTCs. and mutations play a role in about 40% and 15%, respectively, of sporadic MTCs and are predominant drivers in MTC pathways. These mutations are some of the most comprehensively described and screened for in MTC patients; however, in recent studies, other mutations in the gene (p18) have been implicated in the tumorigenesis of MTC.
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