Publications by authors named "Jacorina van Hoften"
Background: An increased risk of major congenital abnormalities after IVF and ICSI has been described, but underlying mechanisms are unclear. This study evaluates the effects of ovarian hyperstimulation, the in vitro procedure and time to pregnancy (TTP) - as proxy for the severity of subfertility - on the prevalence of dysmorphic features.
Design/methods: Participants were singletons born following controlled ovarian hyperstimulation-IVF/ICSI (COH-IVF/ICSI; n=66), or modified natural cycle-IVF/ICSI (MNC-IVF/ICSI; n=56), or to subfertile couples who conceived naturally (Sub-NC; n=86).
Cerebral tissue oxygen saturation and extraction in preterm infants before and after blood transfusion.
Arch Dis Child Fetal Neonatal Ed
September 2010
Objective: Preterm infants often need red blood cell (RBC) transfusions. The aim of this study was to determine whether haemoglobin levels before transfusion were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) and whether RBC transfusions were associated with r(c)SO(2) and FTOE during the 24-h period thereafter.
Design: Prospective observational cohort study.
Article Synopsis
- A significant patent ductus arteriosus (PDA) in preterm newborns can lead to higher health risks, prompting the use of indomethacin for treatment.
- The study monitored 18 preterm infants, measuring their cerebral oxygen levels before and after administering indomethacin to assess its effects.
- Results showed a notable increase in cerebral oxygen extraction shortly after indomethacin treatment, indicating a potential protective mechanism, suggesting further research is needed.