Publications by authors named "Jacopo Agnelli Giacchello"
Article Synopsis
- Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune disorder linked to antiphospholipid syndrome, which causes severe bleeding due to low prothrombin levels, as illustrated by a case study of a 34-year-old woman with heavy menstrual bleeding and related complications.
- The patient underwent extensive testing, revealing deficiencies in factors II and IX, leading to the initiation of immunosuppressive treatment with Rituximab and hormonal therapy with desogestrel to manage antibody levels and reduce bleeding.
- After one year of treatment, the patient achieved complete remission, with restored levels of prothrombin and factor IX while showing reduced antibody
Practical, safe, and effective hemostatic approach to orthopedic surgery using Extended Half-Life factor IX in hemophilia B. By intraindividual comparison, we found a lower FIX consumption, number of infusions, and cost compared to plasma-derived FIX.
View Article and Find Full Text PDFBackground: We have identified a synonymous F8 variation in a severe hemophilia A (HA) patient who developed inhibitors following factor VIII (FVIII) prophylaxis. The unreported c.6273 G > A variant targets the consensus splicing site of exon 21.
View Article and Find Full Text PDFObjectives: To assess long-term treatment patterns and outcomes in patients with persistent or chronic immune thrombocytopenia (ITP), also considering the impact of the treatment with thrombopoietin receptor agonists (TPO-RAs) prior to splenectomy.
Methods: Medical records of all patients with persistent or chronic ITP seen at our institution between January 1985 and December 2016 were reviewed. Data on demographic and clinical characteristics were analyzed using descriptive statistics.