Publications by authors named "Jacobus L Visagie"
Pharmacokinetics of aspirin: evaluating shortcomings in the literature.
Expert Opin Drug Metab Toxicol
August 2024
Article Synopsis
- - Aspirin is effective for preventing strokes and relieving pain, but its toxicity in some individuals is not well understood, particularly regarding the role of glycine conjugation in its detoxification process.
- - A review of existing literature highlighted the pharmacokinetics of aspirin and the factors influencing its metabolism, noting a lack of clarity around individual enzyme contributions and interindividual variation.
- - The review points out the need for more research on the substrate preferences of the enzyme responsible for aspirin activation and emphasizes that impaired glycine conjugation may contribute to serious health issues like Reye's syndrome and cancer.
Article Synopsis
- The stability of nanosized materials, like small cobalt crystallites, is notably different from that of bulk materials.
- In this study, researchers performed a thermodynamic analysis on the oxidation and re-reduction of these small cobalt crystallites, focusing on their behavior as catalysts in the Fischer-Tropsch synthesis.
- The findings indicate that cobalt crystallites smaller than 4.4 nm are prone to oxidation under typical synthesis conditions (specifically, low water to hydrogen pressure ratios and at a temperature of 493 K).