Publications by authors named "Jacobo Alonso-Dominguez"
Article Synopsis
- The study measured plasma cytokine levels in 30 elite controllers (EC) of HIV, comprising 15 transient controllers and 15 persistent controllers.
- Results showed that PWH had higher cytokine levels compared to HIV-uninfected individuals, with EC exhibiting the highest levels.
- Elevated levels of specific cytokines, IP-10 and MIG, were associated with transient controllers and could help predict the loss of viral control, offering potential biomarkers for future HIV management.
Background: Interferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during HIV-1 infection. We assessed their early and long-term dynamics after initiation of antiretroviral treatment (ART).
Methods: Persons with HIV-1 (PWH) aged>18 years starting their first ART in 2015-2021 in a prospective cohort (n=73) were included.
The pandemic caused by SARS-CoV-2 infection has left behind a new symptomatology called post COVID-19, or "long COVID". The pathophysiological mechanisms still remain controversial; however, a link between persistent inflammation and these sequelae has been suggested. Herein, we longitudinally assessed up- and downstream molecules of the NLRP3 inflammasome's pathway in three study groups: healthy donors (HC, n = 14) and donors with a confirmed SARS-CoV-2 infection who had been hospitalized, the latter divided into post COVID-19 (PC, n = 27) and non-post COVID-19 patients (nPC, n = 27) based on the presence or absence of symptomatology at month 6, respectively.
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