Use of an Endotracheal Tube for a Thoracostomy in a Child in Cardiac Arrest: A Case Report.

Background: Traditionally, when patients arrive at an emergency department in cardiac arrest with a concern for a pneumothorax, a thoracostomy tube is placed for decompression. A literature review found no case reports of an endotracheal tube being used in lieu of a thoracostomy tube for a pneumothorax in a child in cardiac arrest.

Case Report: A case of a 4-week-old female infant who presented to the emergency department in cardiac arrest with a pneumothorax is discussed.

Predictors of hepatitis C treatment outcomes in a harm reduction-focused primary care program in New York City.

Background: The social determinants of health that influence steps in the entire Hepatitis C Virus (HCV) treatment cascade must be identified to achieve HCV elimination goals. This project aimed to evaluate the association of these factors with HCV treatment completion and return for sustained virologic response (SVR) testing.

Methods: We used retrospective cohort data from our primary care-based HCV treatment program that provides comprehensive harm reduction care to those who use or formerly used drugs.

A Near-Peer Educational Model for Online, Interactive Learning in Emergency Medicine.

Introduction: The COVID-19 pandemic led to a large disruption in the clinical education of medical students, particularly in-person clinical activities. To address the resulting challenges faced by students interested in emergency medicine (EM), we proposed and held a peer-led, online learning course for rising fourth-year medical students.

Methods: A total of 61 medical students participated in an eight-lecture EM course.

Scaffold hopping approach on the route to selective tankyrase inhibitors.

A virtual screening procedure was applied to identify new tankyrase inhibitors. Through pharmacophore screening of a compounds collection from the SPECS database, the methoxy[l]benzothieno[2,3-c]quinolin-6(5H)-one scaffold was identified as nicotinamide mimetic able to inhibit tankyrase activity at low micromolar concentration. In order to improve potency and selectivity, tandem structure-based and scaffold hopping approaches were carried out over the new scaffold leading to the discovery of the 2-(phenyl)-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one as powerful chemotype suitable for tankyrase inhibition.