Publications by authors named "Jacob W Groenendyk"
Importance: Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for CHD have been studied in several populations, but there is lack of agreement about the incremental value of PRS beyond traditional risk factor scores in the primary prevention of CHD.
View Article and Find Full Text PDFTreatment options for several chronic infectious and inflammatory conditions have expanded in recent years. This may have implications for evolving competing risks for chronic inflammation-associated comorbidities, including cardiovascular diseases (CVDs). Yet sparse data exist on patterns over time in cardiovascular mortality for chronic infectious and inflammatory conditions.
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- Psoriasis patients face a higher risk of heart attacks and increased noncalcified coronary burden, which can be evaluated using coronary computed tomography angiography (CCTA).
- This study utilized machine learning algorithms on data from 263 patients to identify key predictors of noncalcified coronary burden, focusing on variables related to body composition and inflammation.
- The top predictors included factors like body mass index and levels of certain lipoproteins, suggesting that addressing obesity, dyslipidemia, and inflammation is vital in managing psoriasis-related health risks.
Article Synopsis
- The study investigates how inflammation from psoriasis, a chronic inflammatory disease, affects cardiovascular disease (CVD) by looking at aortic vascular uptake and aortic wall thickness in patients.
- Researchers found that the severity of psoriasis correlates with greater aortic wall thickness and uptake of a specific imaging marker called 18F-FDG.
- After a year of psoriasis treatment, participants exhibited reductions in both aortic vascular uptake and wall thickness, highlighting potential links between inflammation and early signs of vascular disease.
Article Synopsis
- The study investigates the effects of biologic therapy on coronary plaque in psoriasis patients, particularly focusing on inflammation-driven plaque types associated with an increased risk of myocardial infarction (MI).
- The research involved 290 participants, with 121 biologic treatment-naïve individuals being analyzed over a one-year period, revealing reduced non-calcified plaque burden and necrotic core in those receiving biologics.
- Results showed a notable 6% reduction in non-calcified plaque and a significant difference in plaque progression between biologic and non-biologic treatments, indicating potential cardiovascular benefits from biologic therapy in these patients.
Article Synopsis
- The study explores the links between chronic stress, as measured by resting amygdala activity, and various cardiovascular health markers in patients with psoriasis, a stress-related inflammatory condition.
- Researchers analyzed data from 164 psoriasis patients and 47 healthy participants, using advanced imaging techniques to assess amygdala and hematopoietic system activity along with cardiovascular indicators.
- Results showed higher amygdala activity in psoriasis patients, correlating with increased hematopoietic activity and subclinical cardiovascular disease markers; treatment of severe psoriasis led to improvements in both skin condition and stress-related measures over one year.
Article Synopsis
- Inflammation plays a key role in the development of atherosclerosis, and psoriasis serves as a model to study early cardiovascular issues due to its association with chronic inflammation.
- This study aims to explore the relationship between aortic vascular inflammation (VI) and various coronary artery disease (CAD) indices in patients with psoriasis.
- Results showed that increased aortic VI correlates with a higher total plaque burden, more luminal stenosis, and a greater presence of high-risk plaques, suggesting a potential link between chronic inflammation and early CAD development.
Atherogenesis has been well demonstrated to proceed in an ordinal fashion. Imaging technologies have advanced substantially in recent decades, enabling early detection of atherosclerosis. Some modalities, such as coronary CT, have seen broad clinical adaptation.
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