Pain distribution in primary care patients with hip osteoarthritis.

Background: Hip osteoarthritis (OA) is the most common diagnosis in primary care adult patients presenting with hip pain but pain location and pain distribution in primary care patients with hip OA have been reported inadequately.

Objective: To describe pain location and pain distribution in primary care patients with clinical and radiographic confirmed hip OA.

Methods: Primary care patients with unilateral clinical and radiographic hip OA living on the island of Funen, Denmark were recruited from primary care to participate in a randomized clinical trial.

Mimetic Divergence and the Speciation Continuum in the Mimic Poison Frog Ranitomeya imitator.

While divergent ecological adaptation can drive speciation, understanding the factors that facilitate or constrain this process remains a major goal in speciation research. Here, we study two mimetic transition zones in the poison frog Ranitomeya imitator, a species that has undergone a Müllerian mimetic radiation to establish four morphs in Peru. We find that mimetic morphs are strongly phenotypically differentiated, producing geographic clines with varying widths.

Number of genes controlling a quantitative trait in a hybrid zone of the aposematic frog Ranitomeya imitator.

The number of genes controlling mimetic traits has been a topic of much research and discussion. In this paper, we examine a mimetic, dendrobatid frog Ranitomeya imitator, which harbours extensive phenotypic variation with multiple mimetic morphs, not unlike the celebrated Heliconius system. However, the genetic basis for this polymorphism is unknown, and not easy to determine using standard experimental approaches, for this hard-to-breed species.

Assessment of algorithms for mitosis detection in breast cancer histopathology images.

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues.

Structure identification in high-resolution transmission electron microscopic images: an example on graphene.

A connection between microscopic structure and macroscopic properties is expected for almost all material systems. High-resolution transmission electron microscopy is a technique offering insight into the atomic structure, but the analysis of large image series can be time consuming. The present work describes a method to automatically estimate the atomic structure in two-dimensional materials.

Reproductive isolation related to mimetic divergence in the poison frog Ranitomeya imitator.

In a mimetic radiation--when a single species evolves to resemble different model species--mimicry can drive within-species morphological diversification, and, potentially, speciation. While mimetic radiations have occurred in a variety of taxa, their role in speciation remains poorly understood. We study the Peruvian poison frog Ranitomeya imitator, a species that has undergone a mimetic radiation into four distinct morphs.

HEp-2 cell classification using shape index histograms with donut-shaped spatial pooling.

We present a new method for automatic classification of indirect immunoflourescence images of HEp-2 cells into different staining pattern classes. Our method is based on a new texture measure called shape index histograms that captures second-order image structure at multiple scales. Moreover, we introduce a spatial decomposition scheme which is radially symmetric and suitable for cell images.