Publications by authors named "Jacob U"

Article Synopsis
  • - The study analyzed the presence of polyphenols in carob pods from Southern Italy using a reliable LC-HRMS method, revealing high levels of Apigenin and Myricetin.
  • - Significant variations in polyphenol content, especially in hesperidin and myricetin, were found between different sampling areas, indicating that geochemical and climatic factors influence these variations.
  • - This research is the first to document the phenolic content of carob pods in this region after harvest and highlights their potential health benefits in preventing oxidative stress-related diseases.
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  • * Most research has focused on protecting brain cells, but it's important to look at the early stages of brain inflammation too.
  • * Some foods, like those in the Mediterranean diet, and certain plant extracts might help reduce inflammation and support brain health, offering new ways to treat these diseases.
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  • Parkinson's disease (PD) arises from the loss of dopamine-producing neurons, leading to symptoms like tremors and poor balance, with factors such as neuroinflammation and oxidative stress contributing to its progression.
  • Research highlights the potential of nutrition in managing neuroinflammation linked to PD, with particular interest in the Burseraceae family of plants for their therapeutic effects.
  • Bioactive compounds from these plants may enhance cognitive function and protect neurons through their anti-inflammatory and antioxidative properties, though more human studies are needed to confirm their neuroprotective potential.
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  • Mitochondria produce reactive oxygen species at moderate levels that are crucial for anti-aging signaling, helping to balance energy and nutrients in cells.
  • Dysregulation of iron regulatory proteins and increased iron levels lead to mitochondrial dysfunction and oxidative stress, contributing to neurodegenerative diseases like Parkinson's and Alzheimer's.
  • Nutritional polyphenols show promise as therapies by regulating the Nrf2 pathway, targeting oxidative stress and neuroinflammation, and providing neuroprotective benefits against cognitive decline.
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The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences.

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The dataset presents a compilation of stomach contents from six demersal fish species from two functional groups inhabiting the Baltic Sea. It includes detailed information on prey identities, body masses, and biomasses recovered from both the fish's digestive systems and their surrounding environment. Environmental parameters, such as salinity and temperature levels, have been integrated to enrich this dataset.

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Objective: This scoping review aims to investigate the available literature on the lived experiences of doing a PhD in African Universities.

Introduction: The continent of Africa still contributes a minimal amount of research towards global research outputs. The need for increased research capacity and outputs have been identified as priority for growth and development.

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The inactivity of people with intellectual disabilities (PwID) is a major contributor to ill health. Probably because people with intellectual disabilities are not adequately informed about physical activity and intervention programs required to enhance their fitness. This study critically reviewed physical activity: benefits and needs for maintenance of quality of life among adults with intellectual disability.

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  • Effective policies to halt biodiversity loss must identify the most significant human-caused drivers, with a focus on recent empirical data.
  • Land and sea use changes are the leading causes of this biodiversity loss globally, followed by direct exploitation of natural resources and pollution.
  • It's essential to address all major drivers and their interactions, as their impact varies across different ecosystems and biodiversity indicators.
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Background: People with intellectual disability are likely to face long-standing employment barriers in finding and keeping jobs, for a variety of reasons. This study, therefore, investigated barriers to employment of people with intellectual disability. The participants in this study were made up of sixty-five stakeholders who were recruited from six different categories.

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Individuals with intellectual disability who suffer from comorbid mental health problems are likely to experience difficulties in socialising. Deficits in social skills are also associated with challenging behaviours and self-injury. This paper presents global evidence from a systematic review of literature on such issues as 'interventions'; 'social skills development', and 'individuals with intellectual disability'.

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Ecological communities face a variety of environmental and anthropogenic stressors acting simultaneously. Stressor impacts can combine additively or can interact, causing synergistic or antagonistic effects. Our knowledge of when and how interactions arise is limited, as most models and experiments only consider the effect of a small number of non-interacting stressors at one or few scales of ecological organization.

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This study investigated the effects of music therapy and pictorial illustration on the attention span of children with mild intellectual difficulties. A pre-test, post-test and control group quasi-experimental research design was used with a sample of children diagnosed with mild intellectual disability from three special schools in Ibadan, Nigeria. Fifty children were randomly selected and assigned to one of three groups: music therapy, pictorial illustration, or control ( = 50, male = 25, female = 25, mean age = 11.

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  • Declining biodiversity and ecosystem functions are threatening many essential benefits that nature provides to people, with a review of 50 years of global trends revealing this issue.
  • Most nature contributions are showing a decrease in their potential to benefit humans, especially in regulating services, although some agricultural and material outputs have actually increased.
  • Environmental declines harm quality of life, but social adaptations and alternatives can help, though they often come with costs and vary significantly among different countries, income levels, and social groups.
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Whereas the conservation and management of biodiversity has become a key issue in environmental sciences and policy in general, the conservation of marine biodiversity faces additional challenges such as the challenges of accessing field sites (e.g. polar, deep sea), knowledge gaps regarding biodiversity trends, high mobility of many organisms in fluid environments, and ecosystem-specific obstacles to stakeholder engagement and governance.

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Valuing, managing and conserving marine biodiversity and a full range of ecosystem services is at the forefront of research and policy agendas. However, biodiversity is being lost at up to a thousand times the average background rate. Traditional disciplinary and siloed conservation approaches are not able to tackle this massive loss of biodiversity because they generally ignore or overlook the interactive and dynamic nature of ecosystems processes, limiting their predictability.

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Recurring economic crises, like the one of 2007-2008, led to criticism of economic research and a demand to develop new strategies to avoid them. Standard economic theories use conventional approaches to deal with economic challenges, heterodox theories try to develop alternatives with which to face them. It remains unclear whether the 2007-2008 crisis led to a change in economic research as well as to a consideration of alternative approaches.

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  • Predator-prey interactions in ecosystems create complex food webs with a universal trend of larger predators compared to their prey, which helps stabilize communities.
  • The study developed predator-trait models to predict body-mass ratios from a comprehensive database of 290 food webs across various ecosystems.
  • It was found that specific predator traits, such as size and movement type, significantly influence the body-size relationships, aiding in understanding and managing ecosystem stability.
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A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single antigen on the surface of AML cells. Here we describe the development and key biological properties of a tri-specific agent, the dual-targeting triplebody SPM-2, with binding sites for target antigens CD33 and CD123, and for CD16 to engage NK cells as cytolytic effectors.

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Managing ecosystems to provide ecosystem services in the face of global change is a pressing challenge for policy and science. Predicting how alternative management actions and changing future conditions will alter services is complicated by interactions among components in ecological and socioeconomic systems. Failure to understand those interactions can lead to detrimental outcomes from management decisions.

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Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expressing cytolytic effectors, including NK and γδ T cells.SPM-1 is an optimized version of triplebody ds(19-16-19) and includes humanization, disulfide stabilization and the removal of potentially immunogenic sequences.

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