Psychopharmacology and pharmacokinetics.

The overall physiologic changes associated with aging lead to changes in both pharmacokinetic and pharmacodynamic actions of many medications. This, in turn, leads to changes in the impact that a wide variety of medications have on older adults when compared to younger, healthy individuals. These pharmacokinetic and pharmacodynamic variations can cause either lesser or greater than expected responses to medication.

Therapeutic Interchange From Rosuvastatin to Atorvastatin in a Veteran Population.

A change in formulary statins was not associated with any differences in liver enzymes or lipid control for patients but did result in significant cost savings at the North Florida/South Georgia Veterans Health System.