Publications by authors named "Jacob T Nelson"
Article Synopsis
- Tick-borne flaviviruses (TBFV) can lead to severe brain diseases, with high rates of long-term neurological issues among survivors.
- Different mechanisms may allow flaviviruses to invade the central nervous system, and the specific method can vary based on the virus, infection site, and host.
- Research using BALB/cJ mice showed that Powassan virus lineages I and II cause differing effects on the CNS and activate distinct immune responses, correlating with unique clinical symptoms.
Background: La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper understanding of LACV-induced neural pathology is needed in order to develop treatment options.
View Article and Find Full Text PDFBackground: Jamestown Canyon virus (JCV), family Bunyaviridae, is a mosquito-borne pathogen endemic in the United States and Canada that can cause encephalitis in humans and is considered an emerging threat to public health. The virus is genetically similar to Inkoo virus circulating in Europe, suggesting that much of the northern hemisphere contains JCV or similar variants.
Results: We have completed the sequence of three isolates of JCV collected in geographically diverse locations over a 57 year time span.
Background: Competitive displacement of a weakly virulent pathogen strain by a more virulent strain is one route to disease emergence. However the mechanisms by which pathogens compete for access to hosts are poorly understood. Among vector-borne pathogens, variation in the ability to infect vectors may effect displacement.
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