Publications by authors named "Jacob Stefka"
Article Synopsis
- The study investigates using HSVtk gene-modified donor lymphocytes to enhance the beneficial graft-versus-leukemia effect while minimizing graft-versus-host disease in patients who have undergone hematopoietic stem cell transplantation.
- Nine patients received infused donor lymphocytes engineered to be sensitive to the anti-herpes drug ganciclovir, showing no toxicities and only one patient developed GVHD, who also had the best anti-tumor response.
- While some patients did not respond to the treatment, the findings suggest that HSVtk-DLI holds potential for effective anti-tumor responses with manageable side effects.
