Publications by authors named "Jacob Santiago Alvarez"
Article Synopsis
- Hepatocellular carcinoma (HCC) is a dangerous type of cancer that is different inside each tumor, making it hard to treat.
- Researchers studied over 600 samples from 123 patients to understand how this cancer develops and progresses.
- They discovered that the most aggressive cells in a tumor are the best way to predict how well a patient will do, not just by looking at how different the tumor cells are from each other.
Hepatocellular carcinoma (HCC) is one of the deadliest cancer types with diverse etiological factors across the world. Although large scale genomic studies have been conducted in different countries, integrative analysis of HCC genomes and ethnic comparison across cohorts are lacking. We first integrated genomes of 1,349 HCC patients from five large cohorts across the world and applied multiple statistical methods in identifying driver genes.
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