Publications by authors named "Jacob S D Valentine"
ACS Chem Biol
October 2024
Article Synopsis
- SICLOPPS is a technique for creating libraries of cyclic peptides that can inhibit specific protein interactions, leading to the discovery of new drug candidates.
- The researchers improved the SICLOPPS screening process by incorporating next-generation sequencing and computational methods, which enhanced the hit rate for potential inhibitors.
- They successfully identified better inhibitors for the HIF-1α/HIF-1β protein interaction, and this new method can be applied to find inhibitors for various other protein targets.
