Publications by authors named "Jacob S Brady"

Article Synopsis
  • The study aimed to analyze trends in the incidence of positive surgical margins in patients with cT1-T2 oral cavity squamous cell carcinoma, assessing the factors influencing this condition from a large dataset.
  • From 2004 to 2016, out of nearly 40,000 patients, 7.95% had positive surgical margins, but there was a trend of decreasing incidence over time, with notable factors like tumor stage and lymphovascular invasion contributing to higher odds of positive margins.
  • The study concludes that treatment at high-volume and academic centers leads to lower rates of positive surgical margins, indicating the importance of treatment quality in outcomes for oral cavity cancer patients.
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Article Synopsis
  • This study analyzes the development of second primary lung malignancies (SPLMs) in patients with head and neck squamous cell carcinoma (HNSCC) and found that 8% of HNSCC patients later developed SPLMs.
  • The study used data from a large cancer database spanning multiple decades to calculate the risk of lung cancer in these patients and identified specific head and neck sites that had higher risks for lung cancer.
  • Results showed that lung cancers following HNSCC were predominantly squamous cell carcinoma, with variations in histology based on the primary head and neck tumor site, indicating distinct risk factors and potential underlying causes.
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Importance: Smoking is a highly prevalent risk factor among patients with head and neck cancer. However, few studies have examined the association of this modifiable risk factor on postoperative outcomes following microvascular reconstruction of the head and neck.

Objective: To analyze the risk associated with smoking in patients undergoing free flap surgery of the head and neck.

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Objectives/hypothesis: To investigate the risk factors for refusal of recommended surgery in head and neck squamous cell carcinoma (HNSCC) treatment STUDY DESIGN: Retrospective review of a national database.

Methods: The Surveillance, Epidemiology, and End Results database was queried for all cases of HNSCC from 1989 to 2014. Patients who underwent recommended surgery (N = 98,270) were identified and compared to patients who refused recommended surgery (N = 3,582).

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Objective: Analyze the risk for perioperative complications associated with body mass index (BMI) class in patients undergoing head and neck free flap reconstruction.

Study Design And Setting: Retrospective cohort study.

Subjects And Methods: The National Surgical Quality Improvement Program (NSQIP) database was queried for all cases of head and neck free flaps between 2005 and 2014 (N = 2187).

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Objective: Diabetes is associated with microvascular pathology and may predispose patients undergoing microvascular surgery to complications. This study assesses diabetes as a risk factor for complications following free flap surgery of the head and neck.

Patients And Methods: In this retrospective cohort study, data on free flap surgeries of the head and neck between 2005 and 2014 was collected from the National Surgical Quality Improvement Program (NSQIP) database.

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Objective: This study is designed to analyze the survival benefits of elective neck dissection (END) in the treatment of squamous cell carcinoma of the maxillary sinus (MS-SCC) with clinically negative neck lymph nodes (N0) and no metastasis (M0).

Study Design: The aim of this study was to evaluate whether END improves survival in patients with MS-SCC.

Methods: This study is a population-based, concurrent retrospective database analysis of patients diagnosed with N0M0 MS-SCC from 2004 to 2013.

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Importance: Prolonged anesthesia and operative times have deleterious effects on surgical outcomes in a variety of procedures. However, data regarding the influence of anesthesia duration on microvascular reconstruction of the head and neck are lacking.

Objective: To examine the association of anesthesia duration with complications after microvascular reconstruction of the head and neck.

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Objectives: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull.

Methods: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied.

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Objectives: Analyze postoperative complications after free flap surgery based on PGY training level.

Methods: Data on free flap surgeries of the head and neck performed from 2005 to 2013 was collected from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database. Cases identifying the status of resident participation in the surgery and the PGY level were included.

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Objectives: To investigate the impact of smoking on complication rates following total laryngectomy.

Study Design And Methods: The National Surgical Quality Improvement Program database was queried for all total laryngectomies between 2005 and 2014. Patients were identified as smokers (n = 561) or nonsmokers (n = 513) and compared via univariate and multivariate analyses.

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Objectives/hypothesis: Analyze postoperative complications of total laryngectomies (TL) in patients with diabetes mellitus and apply these data toward preoperative management of diabetic patients undergoing TL.

Study Design: Retrospective analysis of surgical outcomes database METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried for TL performed between 2005 and 2013. Comparison of demographics, preoperative comorbidities, and postoperative outcomes in a diabetic versus a nondiabetic cohort was conducted using SPSS software.

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Background: Endoscopic sinus surgery (ESS) has become the treatment of choice for a variety of nasal conditions. The purpose of this study was to analyze the effect of diabetes mellitus (DM) on postoperative outcomes in ESS.

Methods: Data on endoscopic sinus surgery performed from 2005 to 2013 were collected from the American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) database.

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Objectives/hypothesis: Unplanned readmissions within 30 days of surgery represent a significant marker for healthcare quality. Small institutional studies have described rates of readmission for patients undergoing head and neck free flap reconstruction. However, large, multi-institutional analyses have not previously been described.

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Objective: Laryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic squamous cell carcinoma treated with either surgery or radiotherapy.

Study Design And Setting: Administrative database study.

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Background: Ventilator-associated pneumonia (VAP) remains a common complication in critically ill surgical patients, and its diagnosis remains problematic. Exhaled breath contains aerosolized droplets that reflect the lung microbiota. We hypothesized that exhaled breath condensate fluid (EBCF) in hygroscopic condenser humidifier/heat and moisture exchanger (HCH/HME) filters would contain bacterial DNA that qualitatively and quantitatively correlate with pathogens isolated from quantitative BAL samples obtained for clinical suspicion of pneumonia.

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