Micro-enema immediately prior to prostate MRI: effects on rectal gas, image quality and PI-QUAL score.

Purpose: Our aim was to determine whether the administration of a micro-enema immediately prior to prostate MRI is associated with a reduction in rectal gas, gas related artifacts and an improvement in image quality and PI-QUAL score.

Method: This retrospective analysis enrolled 171 patients who underwent multiparametric 3T prostate MRI at our institution between January 2021 and September 2022. 86 patients received a micro-enema, and a further 85 patients did not.

Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant colonization when administered an engineered live biotherapeutic.

The gastrointestinal (GI) tract is the reservoir for multidrug resistant (MDR) pathogens, specifically carbapenem-resistant (CR) and other , which often lead to the spread of antimicrobial resistance genes, severe extraintestinal infections, and lethal outcomes. Selective GI decolonization has been proposed as a new strategy for preventing transmission to other body sites and minimizing spreading to susceptible individuals. Here, we purify the to-date uncharacterized class IIb microcin I47 (MccI47) and demonstrate potent inhibition of numerous , including multidrug-resistant clinical isolates, at concentrations resembling those of commonly prescribed antibiotics.

The evolution of spectrum in antibiotics and bacteriocins.

A key property of many antibiotics is that they will kill or inhibit a diverse range of microbial species. This broad-spectrum of activity has its evolutionary roots in ecological competition, whereby bacteria and other microbes use antibiotics to suppress other strains and species. However, many bacteria also use narrow-spectrum toxins, such as bacteriocins, that principally target conspecifics.

Bacterial species rarely work together.

Competition is prevalent and could be harnessed as an alternative to antibiotics.

SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw.

Primary osteosarcomas of the jaw (OSJ) are rare, accounting for 6% of all osteosarcomas. This study aims to determine the value of SATB2 and MDM2 immunohistochemistry (IHC) in differentiating OSJ from other jawbone mimickers, such as benign fibro-osseous lesions (BFOLs) of the jaw or Ewing sarcoma of the jaw. Certain subsets of osteosarcoma harbor a supernumerary ring and/or giant marker chromosomes with amplification of the 12q13-15 region, including the murine double-minute type 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) genes.

An overview of metal homeostasis pathways during infection.

Nutritional immunity is a powerful strategy at the core of the battlefield between host survival and pathogen proliferation. A host can prevent pathogens from accessing biological metals such as Mg, Fe, Zn, Mn, Cu, Co or Ni, or actively intoxicate them with metal overload. While the importance of metal homeostasis for the enteric pathogen Typhimurium was demonstrated many decades ago, inconsistent results across various mouse models, diverse genotypes, and differing infection routes challenge aspects of our understanding of this phenomenon.

A Bioinspired Molybdenum Catalyst for Aqueous Perchlorate Reduction.

Perchlorate (ClO) is a pervasive, harmful, and inert anion on both Earth and Mars. Current technologies for ClO reduction entail either harsh conditions or multicomponent enzymatic processes. Herein, we report a heterogeneous ()Mo-Pd/C catalyst directly prepared from NaMoO, a bidentate nitrogen ligand (), and Pd/C to reduce aqueous ClO into Cl with 1 atm of H at room temperature.

Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant .

Microcin H47 (MccH47) is an antimicrobial peptide produced by some strains of that has demonstrated inhibitory activity against enteric pathogens and has been heterologously overexpressed in proof-of-concept engineered probiotic applications. While most studies clearly demonstrate inhibitory activity against isolates, there are conflicting results on the qualitative capacity for MccH47 to inhibit strains of . Here, we rectify these inconsistencies via the overexpression and purification of a form of MccH47, termed MccH47-monoglycosylated enterobactin (MccH47-MGE).

Remote beam output audits: a global assessment of results out of tolerance.

Background And Purpose: Remote beam output audits, which independently measure an institution's machine calibration, are a common component of independent radiotherapy peer review. This work reviews the results and trends of these audit results across several organisations and geographical regions.

Materials And Methods: Beam output audit results from the Australian Clinical Dosimetry Services, International Atomic Energy Agency, Imaging and Radiation Oncology Core, and Radiation Dosimetry Services were evaluated from 2010 to the present.

Engineered Probiotic for the Inhibition of Salmonella via Tetrathionate-Induced Production of Microcin H47.

Complications arising from antibiotic-resistant bacteria are becoming one of the key issues in modern medicine. Members of drug-resistant Enterobacteriaceae spp. include opportunistic pathogens (e.

Motion of the esophagus due to cardiac motion.

When imaging studies (e.g. CT) are used to quantify morphological changes in an anatomical structure, it is necessary to understand the extent and source of motion which can give imaging artifacts (e.

Low bone mineral density in highly trained male master cyclists.

The purpose of this study was to determine total and regional bone mineral density (BMD) in highly competitive young adult and master male cyclists. Three groups of men were studied: older cyclists (51.2+/-5.