Publications by authors named "Jacob P Ambrose"

Introduction: No professional society guidelines recommend PSA screening in men younger than age 40; however, data suggest testing occurs at meaningful rates in this age group. The purpose of this study was to identify the rate of PSA testing in men under 40.

Methods: This is a population-based, retrospective cohort study from 2008 to 2017.

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Article Synopsis
  • A study was conducted to evaluate the impact of the Choosing Wisely campaign on the use of imaging for men with newly diagnosed prostate cancer, focusing on reducing unnecessary procedures.
  • Analysis of Medicare data from 2007 to 2015 showed a significant decrease in imaging utilization among low-risk patients, with declines in CT and nuclear medicine bone scans.
  • Although the campaign has led to a decrease in unnecessary imaging for low-risk patients, imaging for high-risk patients remains high, suggesting ongoing challenges in promoting guideline-concordant care.
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Unlabelled: Germline likely pathogenic or pathogenic variants (PVs) have been identified in up to 17% of men with prostate cancer (PC) and may drive disease severity or be targetable by novel therapies. National Comprehensive Cancer Network (NCCN) guidelines encouraging germline testing in metastatic PC were recently expanded to include all men with high-risk, very high-risk, or regional PC. Our aim was to assess the impact of expanded NCCN guidelines on the detection rate of germline PVs and to determine patient-level factors associated with a PV germline testing result.

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Background: Low-value prostate-specific antigen (PSA) testing is common yet contributes substantial waste and downstream patient harm. Decision fatigue may represent an actionable target to reduce low-value urologic care. The objective of this study was to determine whether low-value PSA testing patterns by outpatient clinicians are consistent with decision fatigue.

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Introduction: Prostate cancer screening using prostate-specific antigen (PSA) testing remains widespread. The prevalence of PSA testing in young men is unknown and may be an appropriate target for improving health care by decreasing low-value testing in this age group. The purpose of this study was to determine PSA testing rates in men younger than current guidelines support.

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