Publications by authors named "Jacob Ortega"
As diabetes technologies continue to advance, their use is expanding beyond type 1 diabetes to include populations with type 2 diabetes, older adults, pregnant individuals, those with psychiatric conditions, and hospitalized patients. This review examines the psychosocial outcomes of these technologies across these diverse groups, with a focus on treatment satisfaction, quality of life, and self-management behaviors. Despite demonstrated benefits in glycemic outcomes, the adoption and sustained use of these technologies face unique challenges in each population.
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- Pachytene piRNAs, specifically 21URNAs, are believed to regulate non-transposon gene sequences during the process of sperm development (spermatogenesis).
- A disruption in 21URNAs leads to improper homolog pairing and issues with chromosome crossover and segregation, ultimately affecting spermatogenesis.
- Polo-like kinase 3 (PLK-3) is identified as a target of 21URNAs, which restricts its expression in specific cells; the loss of this regulation is linked to defects in the meiotic process.
The centriole, or basal body, is the center of attachment between the sperm head and tail. While the distal end of the centriole templates the cilia, the proximal end associates with the nucleus. Using Drosophila, we identify a centriole-centric mechanism that ensures proper proximal end docking to the nucleus.
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