Publications by authors named "Jacob O'Connor"
Introduction: Despite improved outcomes for many people with cystic fibrosis, there have been reports of adverse neuropsychiatric effects of modulator therapy. The aim of this research is to define temporal associations in adverse drug reaction (ADR) reports for available CFTR modulators.
Methods: Methods include an analysis of the UK Yellow Card Scheme data for ADRs through accessing interactive Drug Analysis Profiles (iDAPs) to define temporal trends in absolute and proportional counts.
Article Synopsis
- Researchers combined computational design and experimental testing to explore how to improve membrane permeability and oral bioavailability in macrocycles.
- They designed 184 macrocycles and confirmed the structures of 35, finding that many closely match their predictions and establishing that specific hydrogen bonding in the molecular structure is key to enhancing permeability.
- Their findings suggest that by carefully manipulating hydrogen bonding interactions, they can develop peptides that efficiently cross membranes and could lead to more effective therapeutic options in the future.