Publications by authors named "Jacob Ninan"

Article Synopsis
  • The study examined 80 Indian patients with choroidal osteoma, focusing on demographic and clinical characteristics as well as treatment outcomes.
  • Most patients were female (61%), with the majority in their second decade of life; various associated complications like choroidal neovascularization (CNV) were noted in 40% of eyes.
  • Treatment methods included anti-VEGF therapy for CNV and other procedures, with mean best corrected visual acuity improving slightly over a follow-up period, indicating the need for ongoing monitoring despite the generally benign nature of the condition.
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Heat stress impacts ruminant livestock production on varied levels in this alarming climate breakdown scenario. The drastic effects of the global climate change-associated heat stress in ruminant livestock demands constructive evaluation of animal performance bordering on effective monitoring systems. In this climate-smart digital age, adoption of advanced and developing Artificial Intelligence (AI) technologies is gaining traction for efficient heat stress management.

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Introduction: Various Machine Learning (ML) models have been used to predict sepsis-associated mortality. We conducted a systematic review to evaluate the methodologies employed in studies to predict mortality among patients with sepsis.

Methods: Following a pre-established protocol registered at the International Prospective Register of Systematic Reviews, we performed a comprehensive search of databases from inception to February 2024.

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Background: Alternate complement dysregulation postrenal transplantation can result in thrombotic microangiopathy (TMA). There is a scarcity of data regarding outcomes based on the timing of TMA post-transplant, coupled with a lack of follow-up biopsy findings post TMA diagnosis. This study aims to assess allograft and patient outcomes in individuals developing early TMA, defined within 4 months post-transplantation, and explore any differences in follow-up surveillance biopsies compared to a non-TMA group.

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Objectives: Conduct a systematic review and meta-analysis to assess prevalence and timing of acute kidney injury (AKI) development after acute respiratory distress syndrome (ARDS) and its association with mortality.

Data Sources: Ovid MEDLINE(R), Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Ovid PsycINFO database, Scopus, and Web of Science thought April 2023.

Study Selection: Titles and abstracts were screened independently and in duplicate to identify eligible studies.

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Background: Urine alkalization is one of the standard treatments to prevent acute kidney injury in patients receiving high-dose methotrexate. Carbonic anhydrase inhibitors are promising adjuvants/substitutes with advantages such as faster urine alkalization time and prevention of fluid overload. However, there is limited and contradictory evidence on its efficacy and safety.

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A man in his 70s presented with a 1-month history of vision loss in the right eye. His best-corrected visual acuity (BCVA) in the affected eye was limited to counting fingers at close range. The examination revealed a macular hole with associated retinal detachment in the right eye and features of pathological myopia in both eyes.

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To assess the relationship between acute kidney injury (AKI) with outcomes among patients requiring extracorporeal membrane oxygenation (ECMO). This is a single-center, retrospective cohort study of adult patients admitted to intensive care units (ICU) at a tertiary referral hospital requiring ECMO from July 1, 2015, to August 30, 2019. We assessed the temporal relationship of AKI and renal replacement therapy with ECMO type (VV vs.

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Acute kidney injury (AKI), which is a common complication of acute illnesses, affects the health of individuals in community, acute care and post-acute care settings. Although the recognition, prevention and management of AKI has advanced over the past decades, its incidence and related morbidity, mortality and health care burden remain overwhelming. The rapid growth of digital technologies has provided a new platform to improve patient care, and reports show demonstrable benefits in care processes and, in some instances, in patient outcomes.

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Vogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute VKH.

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Purpose: To study the effect of increasing grades of hypertensive retinopathy (HTR) on neonatal outcomes among preeclamptic women and assess the various maternal risk factors for HTR.

Methods: A prospective cohort study was conducted on 258 preeclamptic women. The systolic and diastolic blood pressure (SBP and DBP), liver, and renal function parameters were collected besides basic demographic details.

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Purpose: To determine the postoperative en face OCT pattern of closure in idiopathic macular holes (MHs).

Design: Retrospective, multicentric, observational study.

Participants: Patients aged > 18 years with a diagnosis of idiopathic MH, with well documented en face OCT images.

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Unlabelled: The objective of this study was to compare the long-term outcomes of older (50-65 y) type 1 diabetics with body mass index <35 kg/m and type 2 diabetics with body mass index <30 kg/m who received simultaneous pancreas kidney transplantation (SPKT) versus living donor kidney transplants (LDKTs). All subjects had insulin-dependent diabetes.

Methods: This is a retrospective single-center study from July 2003 to March 2021 with a median follow-up of 7.

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Neuroophthalmic manifestations are very rare in corona virus disease-19 (COVID-19) infection. Only few reports have been published till date describing COVID-19-associated neuroophthalmic manifestations. We, hereby, present a series of three cases who developed optic neuritis during the recovery period from COVID-19 infection.

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Context.—: It is unclear if preimplantation frozen section biopsy correlates with outcomes after deceased donor kidney transplantation.

Objective.

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Article Synopsis
  • The study investigates the outcomes and complications associated with sutureless scleral fixated intraocular lens (SFIOL) implantation in patients who suffered from traumatic aphakia in a South Indian eye care center.
  • A total of 45 cases were analyzed, showing significant improvement in visual acuity, although some patients with additional eye issues had poorer outcomes.
  • The findings indicate that while immediate complications were manageable and similar to other studies, longer-term follow-up is necessary to monitor for serious conditions like retinal detachment and glaucoma.
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Kidney transplant (KT) outcomes from high kidney donor profile index (KDPI ≥85%) donors with acute kidney injury (AKI) remain underreported. KT from 172 high KDPI Acute Kidney Injury Network (AKIN) stage 0-1 donors and 76 high KDPI AKIN stage 2-3 donors from a single center were retrospectively assessed. The AKIN 2-3 cohort had more delayed graft function (71% vs.

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Objective: To characterize clinical presentation, laboratory and imaging data, and treatment outcomes for neurosarcoidosis in an urban safety net hospital.

Methods: The research database of Cook County Health and Hospitals system was queried for all cases of sarcoidosis from 2006 to 2013. These cases plus those identified through a survey of neurology faculty were reviewed and flagged if suspected to be neurosarcoidosis.

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