The Essential Role of ClpXP in Requires Species Constrained Substrate Specificity.

The ClpXP protease is a highly conserved AAA+ degradation machine that is present throughout bacteria and in eukaryotic organelles. ClpXP is essential in some bacteria, such as , but dispensible in others, such as . In , ClpXP normally degrades the SocB toxin and increased levels of SocB result in cell death.