Isolated microhematuria in potential kidney donors: evaluating kidney biopsy findings with dipstick urinalysis and urine microscopy results.

Background: Isolated microhematuria (IMH) can signal hidden glomerular disease, necessitating detailed evaluations for potential kidney donors, including kidney biopsies. The optimal strategy for deciding on kidney biopsies remains unclear. While the British Transplant Society supports dipstick analysis, KDIGO focuses solely on urine microscopy.

Disparities in menstrual bleeding management during acute venous thromboembolism treatment: A review of UK practice and a call for clinical studies.

Background: Heavy menstrual bleeding (HMB) is a significant clinical burden for premenopausal individuals treated with anticoagulation for acute venous thromboembolism (VTE). Despite its prevalence, HMB management remains poorly studied, with wide variation in clinical practice.

Objectives: The current study aimed to explore current UK practices in managing HMB in anticoagulated individuals and identify areas requiring clinical research to address disparities.

An Extremely Rare Case of Colonic Leiomyoma Disguised as Pedunculated Colonic Polyp.

Colonic leiomyoma is extremely rare and is endoscopically indistinguishable from gastrointestinal stromal tumor. We present a case of colonic leiomyoma disguised as a pedunculated colonic polyp in a 62-year-old male who underwent surveillance colonoscopy.

Biogeographical distribution of gut microbiome composition and function is partially recapitulated by fecal transplantation into germ-free mice.

Fecal microbiota transplantation has been vital for establishing whether host phenotypes can be conferred through the microbiome. However, whether the existing microbial ecology along the mouse gastrointestinal tract can be recapitulated in germ-free mice colonized with stool remains unknown. We first identified microbes and their predicted functions specific to each of six intestinal regions in three cohorts of specific pathogen-free mice spanning two facilities.

Attitudes Toward Patient Safety Among Final-Year Medical Students and Interns at a Teaching Hospital in Kerala: A Cross-Sectional Study.

Background: With the advancements in medicine, medical technologies, and diagnostics, patient safety is expected to be one of the priorities of modern medicine. However, in India, several medical error-related deaths have been recorded. Medical students today are the future healthcare providers, and hence, understanding their attitudes toward patient safety is crucial.

Unraveling the Clinical Quandary: Cryptic Tuberculosis or Splenogonadal Malignancy?

Tuberculosis continues to persist as a significant health problem in multiple parts of the world despite global efforts to eradicate it. A high variability in the clinical manifestation hinders the early diagnosis. Atypical presentations like "cryptic tuberculosis" lack classic clinical and radiological features of the disease and can mimic metastatic cancer, posing a diagnostic challenge.

Optimizing medication therapy in elderly patients: The impact of medication review using STOPP and START criteria version 2.

Higher prevalence of inappropriate medication use among cancer patients increases risk of drug-related problems(DRP) like drug-drug interactions, ADR, and non-adherence. Potentially inappropriate medication (PIM) and Potential Prescription Omission (PPO) were identified using Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to the Right Treatment (START) criteria. The study objective was to optimize prescriptions for the elderly by analyzing the impact of medication review.

Gliosarcoma: A Multi-Institutional Analysis on Clinical Outcomes and Prognostic Factors.

Purpose: This study describes oncological outcomes and investigates prognostic factors for patients with gliosarcomas (GSM).

Methods: Histopathologically confirmed GSM patients who underwent treatment at five European institutions were retrospectively analyzed.

Results: We analyzed 170 patients with a median clinical follow-up time of 9.

A Prospective Nonrandomized Comparison of Wet Needling Versus Prolotherapy in Myofascial Pain.

Objective: The objective was to analyze the difference between prolotherapy and wet needling (WN) for myofascial trigger points (MTrPs) for the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Clinical Global Impression (CGI), and MTrP count.

Methods: Patients with myofascial pain for 1.5 years were included based on convenience sampling after a pilot study for sample size calculation.

Keraunoparalysis: Fleeting Paralysis Following a Lightning Flash.

Lightning strikes cause a spectrum of manifestations in the human body. Keraunoparalysis is a neurological condition where immediate but transient weakness occurs following a lightning strike. Herein, we report a case of a 45-year-old male with an acute onset of right-sided hemiparesis after a lightning strike.

Variation in attendance at emergency departments in England across local areas: A system under unequal pressure.

Background: Crowding in Accident and Emergency Departments (AEDs) and long waiting times are critical issues contributing to adverse patient outcomes and system inefficiencies. These challenges are exacerbated by varying levels of AED attendance across different local areas, which may reflect underlying disparities in primary care provision and population characteristics.

Method: We used regression analysis to determine how much variation across local areas in England of attendance at emergency departments remained after controlling for population risk factors and alternative urgent care provision.

Stress Assessment in Parents of Children With Autism Spectrum Disorder: A Prospective Case-Control Study.

Background:  Autism spectrum disorder (ASD) is a disorder that is manageable but has no cure. Therefore, it is associated with parental stress, which is often not given importance. Early identification and holistic management of children with ASD are needed.

The long-run effect of COVID-19 on hospital emergency department attendances:evidence from statistical analysis of hospital data from England.

During the COVID-19 pandemic, hospital emergency departments worldwide experienced a pronounced fall in utilisation of emergency care, with a decrease of up to 40% in many countries. Evidence suggests the cause of these changes include both population fear of COVID-19 and the effects of lockdowns and the interaction of these two effects. We analyse a sub-sample of national data on Accident and Emergency (A&E) attendances in England over an extended period from April 2019 to March 2022 for different patient groups, including by age, mental/physical health status, acuity, and common clinical groupings.

Hypoxia regulate developmental coronary angiogenesis potentially through VEGF-R2- and SOX17-mediated signaling.

Background: The development of coronary vessels in embryonic mouse heart involves various progenitor populations, including sinus venosus (SV), endocardium, and proepicardium. ELA/APJ signaling is known to regulate coronary growth from the SV, whereas VEGF-A/VEGF-R2 signaling controls growth from the endocardium. Previous studies suggest hypoxia might regulate coronary growth, but its specific downstream pathways are unclear.

Synergistic metal halide perovskite@metal-organic framework hybrids for photocatalytic CO reduction.

The photocatalytic reduction of carbon dioxide (CO) into multi-electron carbon products remains challenging due to the inherent stability of CO and slow multi-electron transfer kinetics. Here in, we synthesized a hybrid material, cesium copper halide (CsCuI) intercalated onto two-dimensional (2D) cobalt-based zeolite framework (ZIF-9-III) nanosheets (denoted as CsCuI@ZIF-1) through a simple mechanochemical grinding. The synergy in the hybrid effectively reduces CO to carbon monoxide (CO) at 110 μmol/g/h and methane at 5 μmol/g/h with high selectivity, suppressing hydrogen evolution.

Dry-ageing impacts on meat quality, oxidative stability, and release of free amino acids in striploins from dairy crossbred yearling and 2-year-old steers.

This study determined the impacts of dry-ageing on meat quality, oxidative stability, and release of free amino acids (FAAs) in striploins from dairy-crossbred yearlings and 2-year-old steers (n = 12 each group) over 21 days of in-bag dry-ageing. Dry-ageing increased weight losses, with higher % drying rates in yearling meat during dry-ageing, likely due to the smaller loin size and lower intramuscular fat content (P < 0.05).

Co-production of guidance and resources to implement principled participant information leaflets (PrinciPILs).

Background: The way information about potential benefits and harms of trial is presented within participant information leaflets (PILs) varies widely and may cause unnecessary 'nocebo' effects. The Medical Research Council (MRC) funded a project that developed seven principles to reduce this variation. However, guidance has not been produced to facilitate the implementation of the principles.

PULSE Ambassadors program: empowering departments to transform STEM education for inclusion and student success.

The Partnership for Undergraduate Life Sciences Education (PULSE) is a non-profit educational organization committed to promoting the transformation of undergraduate STEM education by supporting departments in removing barriers to access, equity, and inclusion and in adopting evidence-based teaching and learning practices. The PULSE Ambassadors Campus Workshop program enables faculty and staff members of host departments to 1) develop communication, shared leadership, and inclusion skills for effective team learning; 2) implement facilitative leadership skills (e.g.

Dairy versus non-dairy cheese texture: Sensory and instrumental contrasts.

With growing consumer demand for plant-based products that mimic the eating experience of animal-based products, there is a need for improvement in instrumental measurements of sensory texture. This study aimed to characterize textural differences between dairy and non-dairy cheeses, and to investigate whether Large Amplitude Oscillatory Shear (LAOS) rheometry could discriminate sensory texture better than Texture profile analysis. Commercial dairy and non-dairy cheddar, mozzarella, and cream cheese were selected to provide a wide range of textures.