Background: Despite major efforts in prevention, surgical site infections (SSIs) remain a burden on patients and the healthcare system and are associated with significant morbidity. SSIs are one of the costliest healthcare-associated infections. The diagnosis of SSIs is based mainly on clinical assessment, which may result in a delay in detection.
View Article and Find Full Text PDFLong-term monitoring of wildlife numbers traditionally uses observers, which are frequently inefficient and inaccurate due to their variable experience/training, are costly and difficult to sustain over time. Furthermore, there are other inhibiting factors for wildlife counting, such as: inhabiting inaccessible areas, fear of humans, and nocturnal behavior. There is a need to develop new technologies that will automatically identify and count wild animals in order to determine the appropriate management protocol.
View Article and Find Full Text PDFExpression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of proteins. Having implications in both directions fosters the possibility of an "improve it or lose it" feedback loop, where higher expressed systems are more likely to improve and be expressed even higher, while those that are expressed less are eventually lost to drift.
View Article and Find Full Text PDFThe adherens junctions between epithelial cells involve a protein complex formed by E-cadherin, β-catenin, α-catenin and F-actin. The stability of this complex was a puzzle for many years, since in vitro studies could reconstitute various stable subsets of the individual proteins, but never the entirety. The missing ingredient turned out to be mechanical tension: a recent experiment that applied physiological forces to the complex with an optical tweezer dramatically increased its lifetime, a phenomenon known as catch bonding.
View Article and Find Full Text PDFObjective: Previous single-center studies have reported that up to 40% of children hospitalized for asthma will be readmitted. The study objectives are to investigate the prevalence and timing of 30-day readmissions in children hospitalized with asthma, and to identify factors associated with 30-day readmissions.
Methods: Data (n = 12,842) for children aged 6-18 years hospitalized for asthma were obtained from the 2013 Nationwide Readmission Database (NRD).