Publications by authors named "Jacob M Kadamapuzha"
Background: The role of adjuvant therapy in resected periampullary adenocarcinomas is equivocal due to contrasting data and limited prospective trials.
Methods: The Multicentre Indian Pancreatic & Periampullary Adenocarcinoma Project (MIPPAP), included data from 8 institutions across India. Of the 1679 pancreatic resections, 736 patients with T3/T4 and/or Node positive adenocarcinomas (considered as high risk for recurrence) were included for analysis.
Practice Patterns and Survival in Patients with Resected Pancreatic Ductal Adenocarcinomas (PDAC) - Results from the Multicentre Indian Pancreatic & Periampullary Adenocarcinoma Project (MIPPAP) Study.
J Gastrointest Cancer
December 2023
Article Synopsis
- Limited data on the presentation and outcomes of surgically treated pancreatic ductal adenocarcinomas (PDACs) in India prompted a study involving 288 patients from 8 academic centers from January 2015 to June 2019.
- The study found an 81% rate of R0 resection and a median overall survival of 45 months, with significant differences in disease-free survival (DFS) based on cancer stage and the presence of perineural invasion (PNI).
- Overall, the MIPPAP study indicates that the survivals for resectable PDACs in India are comparable to global data, while suggesting that adjuvant radiotherapy may not improve outcomes after complete resection.
Surgeons and endoscopists welcome routine preoperative biliary drainage prior to pancreaticoduodenectomy despite evidence that it increases complications. Its effect on postoperative pancreatic fistula is variably reported in literature. Simultaneous biliary and pancreatic drainage is rarely performed for very selected indications and its effects on postoperative pancreatic fistula are largely unknown.
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