Evaluation of a trough-only extrapolated area under the curve vancomycin dosing method on clinical outcomes.

Background Vancomycin dosing strategies targeting trough concentrations of 15-20 mg/L are no longer supported due to lack of efficacy evidence and increased risk of nephrotoxicity. Area-under-the-curve (AUC) nomograms have demonstrated adequate attainment of AUC goals ≥ 400 mg h/L with more conservative troughs (10-15 mg/L). Objective The purpose of this study is to clinically validate a vancomycin AUC dosing nomogram compared to conventional dosing methods with regards to therapeutic failure and rates of acute kidney injury.

Accuracy of Antiretroviral Prescribing in a Community Teaching Hospital: A Medication Use Evaluation.

Background: Medication errors account for nearly 250 000 deaths in the United States annually, with approximately 60% of errors occurring during transitions of care. Previous studies demonstrated that almost 80% of participants with human immunodeficiency virus (HIV) have experienced a medication error related to their antiretroviral therapy (ART).

Objective: This retrospective chart review examines propensity and type of ART-related errors and further seeks to identify risk factors associated with higher error rates.