Publications by authors named "Jacob Lescher"
Peroneal neuropathy is a common pathology encountered by neurosurgeons. Symptoms include pain, numbness, and foot drop. When secondary to compression of the nerve at the fibular head, peroneal (fibular) nerve release is a low-risk procedure that can provide excellent results with pain relief and return of function.
View Article and Find Full Text PDFObjective: Metrics of diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) can detect diffuse axonal injury in traumatic brain injury (TBI). The relationship between the changes in these imaging measures and the underlying pathologies is still relatively unknown. This study investigated the radiological-pathological correlation between these imaging techniques and immunohistochemistry using a closed head rat model of TBI.
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- Spontaneous mild ventriculomegaly (MVM) was found in about 43% of Wistar rats, often linked to vascular issues without visible symptoms.
- This study examined how MVM affects injury responses in rats after mild traumatic brain injury (TBI), using various imaging techniques to analyze differences between MVM and normal rats.
- Findings revealed that MVM rats showed less axonal injury and increased inflammation compared to normal rats, indicating that pre-screening for MVM is essential before conducting TBI research to ensure accurate interpretation of imaging results.
Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment.
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- Wistar rats are a common model for neuroscience research, but our study revealed that 43.2% had mild spontaneous ventriculomegaly, which went unnoticed before.
- Advanced imaging techniques showed various neurological abnormalities linked to this condition, including aneurysms and arteriovenous malformations.
- Our findings highlight the need for baseline imaging in rat studies to reduce variability and improve the accuracy of results in neurological research.
Background: After central nervous system injury, inflammatory macrophages (M1) predominate over anti-inflammatory macrophages (M2). The temporal profile of M1/M2 phenotypes in macrophages and microglia after traumatic brain injury (TBI) in rats is unknown. We subjected female rats to severe controlled cortical impact (CCI) and examined the postinjury M1/M2 time course in their brains.
View Article and Find Full Text PDFIschemic stroke affects ∼795,000 people each year in the U.S., which results in an estimated annual cost of $73.
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