Publications by authors named "Jacob K Thomas"
Purpose: To compare the prevalence of endothelial rejection episodes and the probability of graft survival after initial and repeat penetrating keratoplasty (PK) in patients with keratoconus with and without atopy.
Methods: A retrospective review was conducted of all patients receiving PK for keratoconus at the University of Texas Southwestern Medical Center at Dallas from 1988 to 2009. Inclusion criteria involved those with both an International Classification of Diseases-9 code for keratoconus and a Current Procedural Terminology code for PK based on a computer database search.
Article Synopsis
- The study evaluated how the antibiotic ceftobiprole is absorbed and distributed in bone tissue after being given to uninfected New Zealand White rabbits via subcutaneous injection.
- Higher doses of ceftobiprole (80 mg/kg) showed proportional increases in serum exposure and effective distribution in bone compared to lower doses (20 mg/kg), without drug accumulation over time.
- In a separate experiment on a rabbit model of osteomyelitis, ceftobiprole effectively reduced bacterial levels in infected bones more than other antibiotics tested, demonstrating its potential as a treatment option for resistant infections.