Publications by authors named "Jacob Jincy"

Article Synopsis
  • Bleeding in the pleural space can lead to retained hemothorax (RH), causing lung issues and shortness of breath due to clot formation.
  • Researchers tested single-chain urokinase (scuPA) for intrapleural clot dissolution in a rabbit model, comparing its effectiveness against another agent, single-chain tissue plasminogen activator (sctPA).
  • Results indicated that delivering two doses of scuPA was more effective than a single higher dose, and both agents were equally capable of clearing clots and promoting fluid drainage, though more clinical trials are needed to determine the best treatment approach.
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Retained hemothorax (RH) is a commonly encountered and potentially severe complication of intrapleural bleeding that can organize with lung restriction. Early surgical intervention and intrapleural fibrinolytic therapy have been advocated. However, the lack of a reliable, cost-effective model amenable to interventional testing has hampered our understanding of the role of pharmacological interventions in RH management.

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The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A -induced rabbit model of chronic empyema recapitulates the progression, loculation, fibrotic repair, and pleural thickening of human disease.

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Ethnopharmacological Relevance: Medicinal plants have been used by the people of developing countries to treat various diseases. WHO also recommends the use of medicines from plants source. In that, diabetes also one of the diseases that have been treated traditionally by several people all over the world.

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