Publications by authors named "Jacob J Jeziorski"
Article Synopsis
- Microglia, although typically known for their immune functions in the central nervous system, also play crucial roles in brain development that are not yet fully understood, especially in humans.
- Researchers used human microglia-like cells with a deleted MECP2 gene to study its impact, discovering that this disruption led to significant issues in cell functions like phagocytosis and synapse formation.
- A drug called ADH-503 was found to enhance phagocytosis and restore normal synapse formation, offering potential new treatment options for conditions linked to MECP2 abnormalities in mice.
The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without exacerbating pain. Induced pluripotent stem cells (iPSC) may be administered by autologous transplantation, avoiding immunologic challenges. Identifying strategies to optimize iPSC-derived neural progenitor cells (hiNPC) for cell transplantation is an important objective.
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