Publications by authors named "Jacob Hallion"
Article Synopsis
- Colon adenocarcinoma is a leading cause of cancer deaths globally, with the epithelial-mesenchymal transition process playing a key role in cancer metastasis.
- An analysis identified the long non-coding RNA ZFAS1 as significantly elevated in colon cancer compared to normal tissue, and this was validated through further testing.
- ZFAS1 knockdown reduced cell proliferation, migration, and invasion in colon cancer cell lines, revealing its critical role in regulating the miR-200/ZEB1/E-cadherin and vimentin signaling pathway, with implications for tumor growth in vivo.
Background: Ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative colitis. Afferent limb stenosis is an infrequent complication following IPAA, suggesting underlying Crohn's disease (CD). We hypothesized that CD-related single nucleotide polymorphisms (SNPs) are associated with afferent limb stenosis.
View Article and Find Full Text PDFIntroduction: Current serological surveillance markers to monitor colorectal cancer (CRC) or colorectal advanced adenomas (CAA) are hampered by poor sensitivity and specificity. The aim of this study is to identify and validate a panel of plasma microRNAs which change in expression after resection of such lesions.
Methods: A prospectively maintained colorectal surgery database was queried for patients in whom both pre- and post-procedural serum samples had been obtained.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related death. Epithelial-mesenchymal transition (EMT) is a major process in tumor metastasis development. This systematic review aims to describe the role of long non-coding RNA (lncRNA) in EMT in CRC.
View Article and Find Full Text PDFColorectal cancer (CRC) is associated with significant morbidity and mortality as many patients are diagnosed with advanced stage disease. MicroRNAs are small, noncoding RNA molecules that have a major role in gene expression regulation and are dysregulated in CRC. The miR-200 family is involved in epithelial-mesenchymal transition (EMT).
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