Publications by authors named "Jacob H ten Veen"

Article Synopsis
  • Nephrolithiasis, a common side effect of indinavir treatment for HIV, can lead to serious urological issues like renal colic and insufficiency.
  • The study analyzed 1219 HIV patients in the Netherlands, finding that urological symptoms occurred significantly more often in those treated with indinavir compared to other protease inhibitors (8.3 vs. 0.8 per 100 treatment-years).
  • Key risk factors for developing these symptoms included low weight, low lean body mass, undetectable HIV-1 RNA at treatment initiation, prior treatment intolerance, high-dose indinavir regimens, and warm environmental conditions.
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There is little information about the risk of treatment failure after a switch from human immunodeficiency virus (HIV) protease inhibitors (PIs) to nevirapine (Nvp) for patients with successful virus suppression. This study compared the 1-year risk of treatment failure for patients switching from a first PI-containing antiretroviral regimen to Nvp (Nvp group) with the risk for patients switching to second-line PIs (PI group) in the ATHENA (AIDS Therapy Evaluation, The Netherlands) study cohort (n=2470) whose HIV-1 RNA loads were < or = 500 copies/mL. Treatment failure was defined as measurement of HIV-1 RNA loads >500 twice or >10,000 copies/mL once or discontinuation of treatment for any reason.

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