Publications by authors named "Jacob Fang"
Article Synopsis
- Near-tetraploidy/tetraploidy (NT/T) is a genetic change found in acute myeloid leukemia (AML), which affects prognosis and is more prevalent in older males with specific blood abnormalities.
- A study revealed that 77.8% of NT/T AML cases showed dysgranulopoiesis, and most patients had multiple genetic abnormalities, with a significant portion exhibiting NT/T as the only abnormality.
- Among those treated for NT/T AML, 80% reached complete remission, but the overall survival rate was low, with a median of just 4.5 months.
Predictors for response to intensive therapy in AML have focused on baseline factors: percent leukemic blasts in marrow, cytogenetic/molecular genetic abnormalities, and presence of secondary AML. Non-baseline dynamic factors, occurring after induction but before response, may be useful for decisions related to salvage chemotherapy. We hypothesized white blood cell (WBC) count nadir after induction may be a real time indicator of treatment efficacy.
View Article and Find Full Text PDFThe pathophysiology behind sodium retention in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. We hypothesized that patients with HFpEF have impaired natriuresis and diuresis in response to volume expansion and diuretic challenge, which is associated with renal hypo-responsiveness to endogenous natriuretic peptides. Nine HFpEF patients and five controls received saline infusion (0.
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