Publications by authors named "Jacob Elliott"
Tendinopathies account for 30% of 102 million annual musculoskeletal injuries occurring annually in the United States. Current treatments, like dry needling, induce microdamage to promote healing but produce mixed success rates. Previously, we showed focused ultrasound can noninvasively create microdamage while preserving mechanical properties in ex vivo murine tendons.
View Article and Find Full Text PDFMacrophages are specialized phagocytes that play central roles in immunity and tissue repair. Their diverse functionalities have led to an evolution of new allogenic and autologous macrophage products. However, realizing the full therapeutic potential of these cell-based therapies requires development of imaging technologies that can track immune cell migration within tissues in real-time.
View Article and Find Full Text PDFTendon injuries are extremely common, resulting in mechanically weaker tendons that could lead to tendon rupture. Dry needling (DN) is widely used to manage pain and function after injury. However, DN is invasive and high inter-practitioner variability has led to mixed success rates.
View Article and Find Full Text PDFFocused Ultrasound Mechanical Disruption of Ex Vivo Rat Tendon.
IEEE Trans Ultrason Ferroelectr Freq Control
September 2021
Article Synopsis
- Around 30 million tendon injuries occur each year in the U.S., costing around $114 billion, with traditional treatments like dry needling showing inconsistent success.
- Focused ultrasound (fUS) therapy utilizes bubble dynamics through a process called histotripsy to try and break down tough collagenous tissues like tendons, which are typically resistant to such mechanical disruption.
- This study tested fUS on rat tendons and found that while bubbles were consistently created, not all samples sustained histological injury; successful disruption was most evident with specific pulse durations and treatment parameters, indicating potential for fUS in treating tendon injuries.