Investigating the Impact of Drone Transport on the Stability of Monoclonal Antibodies for Inter-Hospital Transportation.

In the field of healthcare logistics, the reliance on conventional transport methods such as cars for the delivery of monoclonal antibodies (mAbs) is susceptible to challenges posed by traffic and infrastructure, leading to increased and unpredictable transport times. Recognizing the potential role of drones in mitigating these challenges, we aimed to investigate the impact of medical drone transport on the stability of mAbs. Compromised stability could lead to aggregation and immunogenicity, thereby jeopardizing the efficacy and safety of mAbs.

Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates?

Objective: An easy to establish and patient-friendly biomarker to guide dosing of paracetamol in neonates is currently not available. The aim of this study was to determine the potential association between the serum trough concentration and area under the curve (AUC) of paracetamol at steady state and differences in pain scores in preterm and term neonates.

Materials And Methods: A retrospective observational study was performed, using an academic hospital database to identify neonates treated with intravenous or rectal paracetamol for at least 48 hours.

Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis.

Background: Antibiotic use prior to biopsy acquisition in people with diabetes and osteomyelitis of the foot (DFO) might influence bacterial yield in cultures or induce bacterial resistance. Obtaining reliable culture results is pivotal to guide antibiotics for conservative treatment of DFO.

Methods: We prospectively analysed cultures of ulcer bed and percutaneous bone biopsies of people with DFO and investigated if antibiotics administered prior to (<2 months up to 7 days) biopsy acquisition led to more negative cultures or increased resistance in virulent bacteria.

Optimizing Antiviral Dosing for HSV and CMV Treatment in Immunocompromised Patients.

Herpes simplex virus (HSV) and cytomegalovirus (CMV) are DNA viruses that are common among humans. Severely immunocompromised patients are at increased risk of developing HSV or CMV disease due to a weakened immune system. Antiviral therapy can be challenging because these drugs have a narrow therapeutic window and show significant pharmacokinetic variability.

The Role of Community in Understanding Involvement in Community Energy Initiatives.

Community energy initiatives are set up by volunteers in local communities to promote sustainable energy behaviors and help to facilitate a sustainable energy transition. A key question is what motivates people to be involved in such initiatives. We propose that next to a stronger personal motivation for sustainable energy, people's perception that their community is motivated to engage in sustainable energy and their involvement in the community (i.

Modeling the micro-macro link: Understanding macro-level outcomes using randomization tests on micro-level data.

Analytical sociology explains macro-level outcomes by referring to micro-level behaviors, and its hypotheses thus take macro-level entities (e.g. groups) as their units of analysis.

The impact of self-perceived limitations, stigma and sense of coherence on quality of life in multiple sclerosis patients: results of a cross-sectional study.

Objective: To examine the impact of perceived limitations, stigma and sense of coherence on quality of life in multiple sclerosis patients.

Design: Cross-sectional survey.

Setting: Department of Neurology, University Medical Center Groningen, the Netherlands.

Relative power: Material and contextual elements of efficacy in social dilemmas.

In Step-Level Public Good (SPG) situations, groups of individuals can produce a public good if a sufficient number of them contribute. In SPG situations it is thus only rational for any group member to contribute if according to the beliefs of that group member her contribution is essential to the production of the public good. An individual's estimate of the impact of their contribution on the likelihood of public good production is known as their efficacy.

Quantification of co-trimoxazole in serum and plasma using MS/MS.

Background: Co-trimoxazole is frequently used in the prophylaxis and treatment of Pneumocystis carinii pneumonia. High plasma concentrations of sulfamethoxazole or trimethoprim are correlated with toxicity. There is, however, a large variation in PK observed which can lead to underexposure or toxicity.

Quantification of amikacin and kanamycin in serum using a simple and validated LC-MS/MS method.

Background: Amikacin and kanamycin are frequently used in the treatment of multidrug-resistant TB. The current commercially available immunoassay is unable to analyze kanamycin and trough levels of amikacin. The objective was therefore to develop a LC-MS/MS method for the quantification of amikacin and kanamycin in human serum.

Do intergroup conflicts necessarily result from outgroup hate?

We developed a new experimental design to test whether or not individuals engage in conflict between social groups because they seek to harm outgroup members. Challenging prominent social psychological theories, we did not find support for such negative social preferences. Nevertheless, subjects heavily engaged in group conflict.