Publications by authors named "Jacob D Hinkle"

Purpose: Deep learning (DL) models have received much attention lately for their ability to achieve expert-level performance on the accurate automated analysis of chest X-rays (CXRs). Recently available public CXR datasets include high resolution images, but state-of-the-art models are trained on reduced size images due to limitations on graphics processing unit memory and training time. As computing hardware continues to advance, it has become feasible to train deep convolutional neural networks on high-resolution images without sacrificing detail by downscaling.

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We introduce a deep learning architecture, hierarchical self-attention networks (HiSANs), designed for classifying pathology reports and show how its unique architecture leads to a new state-of-the-art in accuracy, faster training, and clear interpretability. We evaluate performance on a corpus of 374,899 pathology reports obtained from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) program. Each pathology report is associated with five clinical classification tasks - site, laterality, behavior, histology, and grade.

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Article Synopsis
  • Automated text extraction from cancer pathology reports is important for national cancer tracking, but creating versatile tools for different registries is challenging.
  • This study tested whether transfer learning using a convolutional neural network can help share knowledge between cancer registries.
  • The results showed that using transfer learning improved classification performance, particularly for less common cancer types, suggesting a more effective approach to information extraction across registries.
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Background: Substrate accessibility to catalysts has been a dominant theme in theories of biomass deconstruction. However, current methods of quantifying accessibility do not elucidate mechanisms for increased accessibility due to changes in microstructure following pretreatment.

Results: We introduce methods for characterization of surface accessibility based on fine-scale microstructure of the plant cell wall as revealed by 3D electron tomography.

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