Publications by authors named "Jacob Christ"
Context: The 2018 International Evidence Based Guidelines (IEBG) for PCOS were created, in part, in response to poor patient satisfaction on international surveys. Patient satisfaction in the US, before and after these guidelines has not yet been characterized.
Objective: To evaluate care patterns and patient attitudes among women with PCOS in the US before and after IEBG.
While highly prevalent, risk factors for incident polycystic ovary syndrome (PCOS) are poorly delineated. Using a population-based cohort, we sought to identify predictors of incident PCOS diagnosis. A matched case-control analysis was completed utilizing patients enrolled in Kaiser Permanente Washington from 2006 to 2019.
View Article and Find Full Text PDFObjective: To study the impact of vigorous vs. moderate exercise on metabolic parameters in polycystic ovary syndrome (PCOS).
Design: Randomized controlled trial.
Study Objectives: Risk of obstructive sleep apnea (OSA) appears to be increased among patients with polycystic ovary syndrome (PCOS), but the underlying physiology is unclear. We sought to identify predictors of OSA risk among patients with PCOS.
Methods: A cross-sectional analysis of patients evaluated for PCOS at a single tertiary center from 2017-2022 was completed.
Background: Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, yet US incidence estimates do not exist, and prevalence estimates vary widely.
Objective: A population-based US study estimated the incidence, prevalence, and trends of polycystic ovary syndrome by age, race and ethnicity, and diagnosing provider type.
Study Design: A retrospective cohort study of patients enrolled in Kaiser Permanente Washington from 2006 to 2019 was conducted.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-aged women. Much of the confusion surrounding PCOS diagnosis stems from the broad heterogeneity of symptomology experienced by women with PCOS. The diverse features of the syndrome have led to a number of diagnostic criteria over the years.
View Article and Find Full Text PDFResearch Question: Which patient features predict the time to pregnancy (TTP) leading to term live birth in infertile women diagnosed with polycystic ovary syndrome (PCOS)?
Design: Prospective cohort follow-up study was completed, in which initial standardized phenotyping was conducted at two Dutch university medical centres from January 2004 to January 2014. Data were linked to the Netherlands Perinatal Registry to obtain pregnancy outcomes for each participant. All women underwent treatment according to a standardized protocol, starting with ovulation induction as first-line treatment.
Objective: To provide a review of the current literature surrounding barriers to reproductive medicine and present examples of how resident and fellow education can be used to overcome these barriers.
Design: A review of the relevant literature addressing barriers to reproductive medicine, resident and fellow education, and related materials was completed.
Setting: Academic medical institutions.
Background: Accurate estimates of incidence and prevalence of endometriosis among nonselected cohorts are lacking in the United States, and earlier reports have produced varying results.
Objective: This study aimed to define endometriosis incidence and prevalence in a US population and evaluate factors influencing these estimates over time.
Study Design: A 10-year retrospective cohort study using Kaiser Permanente Washington electronic health records database was completed.
Article Synopsis
- This study reports three cases of severe ovarian hyperstimulation syndrome (OHSS) in oncofertility patients who received a long-acting GnRH agonist after controlled ovarian hyperstimulation (COH) and embryo freezing.! -
- All three patients developed serious symptoms, including ascites and hyponatremia, indicative of severe early-onset OHSS despite using a GnRH agonist trigger to minimize risks.! -
- The findings suggest that using a long-acting GnRH agonist right after oocyte retrieval may heighten the risk of severe OHSS, prompting a recommendation to delay its initiation for high-risk patients.!
Background: Women diagnosed with polycystic ovary syndrome (PCOS) suffer from an unfavorable cardiometabolic risk profile, which is already established by child-bearing age.
Objective And Rationale: The aim of this systematic review along with an individual participant data meta-analysis is to evaluate whether cardiometabolic features in the offspring (females and males aged 1-18 years) of women with PCOS (OPCOS) are less favorable compared to the offspring of healthy controls.
Search Methods: PubMed, Embase and gray literature databases were searched by three authors independently (M.
Context: Women with polycystic ovary syndrome (PCOS) are at increased risk for obstetric and perinatal complications. At present, it is unknown how characteristics of PCOS relate to the likelihood of these complications.
Objective: To evaluate which preconception features are associated with obstetric and perinatal disease among infertile women with PCOS.
Objective: To evaluate the association between estrogen (E) exposure and deficiency and cardiovascular disease (CVD) risk among women with primary ovarian insufficiency (POI).
Design: Cross-sectional study conducted between 1996 and 2016.
Setting: Tertiary referral centers.
Objective: To characterize the impact of bariatric surgery on reproductive and metabolic features common to polycystic ovary syndrome (PCOS) and to assess the relevance of preoperative evaluations in predicting likelihood of benefit from surgery.
Methods: A retrospective chart review of records from 930 women who had undergone bariatric surgery at the Cleveland Clinic Foundation from 2009 to 2014 was completed. Cases of PCOS were identified from ICD coding and healthy women with pelvic ultrasound evaluations were identified using Healthcare Common Procedure Coding System coding.
Article Synopsis
- - The study aimed to evaluate the relationship between polycystic ovarian morphology (PCOM) and symptom severity in women with polycystic ovary syndrome (PCOS) using advanced ultrasound technology.
- - It involved 49 women diagnosed with PCOS, focusing on ultrasound measurements like antral follicle count (AFC) and ovarian volume (OV), along with various hormonal and metabolic parameters.
- - Findings indicated that AFC correlated positively with androgen levels and hormonal ratios, suggesting that AFC is a better indicator of reproductive dysfunction in PCOS than OV, while different follicle sizes showed varying associations with metabolic dysfunction.
Objective: To compare the diagnostic potential of ultrasonographic markers of ovarian morphology, used alone or in combination, to predict polycystic ovary syndrome (PCOS).
Design: A diagnostic test study using cross-sectional data collected from 2006-2011.
Setting: Academic hospital and clinical research unit.