Publications by authors named "Jacob C Holter"
Blood and lymphatic vessels in the body are central to molecular and cellular transport, tissue repair, and pathophysiology. Several approaches have been employed for engineering microfabricated blood and lymphatic vessels , yet traditionally these approaches require specialized equipment, facilities, and research training beyond the capabilities of many biomedical laboratories. Here we present xurography as an inexpensive, accessible, and versatile rapid prototyping technique for engineering cylindrical and lumenized microvessels.
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- Cancer-associated fibroblasts (CAFs) aid in tumor development by remodeling the tumor environment and secreting chemokines like CXCL12, which is linked to cancer progression.
- A study using a 3-D microfluidic model showed that CXCL12 from CAFs increases the permeability of blood vessel analogs, suggesting it helps tumors grow and spread.
- While CXCL12 promotes a more permeable endothelium that supports tumor activities, it does not significantly drive the contractility of CAFs themselves, indicating a complex interaction in the tumor microenvironment.