Publications by authors named "Jacob C A Edvinsson"
Background: The purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localization of hormones and neuropeptides with relevance to migraine (vasopressin, oxytocin, estrogen, progesterone, testosterone, amylin, adrenomedullin and calcitonin gene-related peptide (CGRP)) in human intracranial arteries.
Methods: Human cortical cerebral and middle meningeal arteries were used in this study. The tissues were removed in conjunction with neurosurgery and donated with consent.
Article Synopsis
- Calcitonin gene-related peptide (CGRP) is a significant member of the calcitonin family and is concentrated in the trigeminovascular system (TVS), which is relevant for migraine treatment.
- The study involved dissection of trigeminal ganglia from male and female rats, assessing the expression of various peptides and their receptors using techniques like immunohistochemistry and RT-qPCR.
- Results indicated a higher expression of CGRP mRNA in both genders, a notable increase of receptor activity-modifying protein-1 (RAMP1) in females, and the presence of varying peptides and receptors localized in the TG neurons, emphasizing CGRP's crucial role in the TVS.