Publications by authors named "Jacob Arche"
Article Synopsis
- Merkel cell carcinoma (MCC) is a serious skin cancer linked to the Merkel cell polyomavirus and exhibits specific gene expressions related to Merkel cell development.
- Researchers used a method called in vivo cellular reprogramming with the ATOH1 gene to induce MCC-like tumors in mice from skin cells.
- The study found that the development of these tumors required the loss of the p53 protein, mirroring the dysfunction of p53 observed in human MCC cases.
The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated by some viruses to favor infection. However, mechanisms of metabolic modulation and their effects on viral replication vary widely. Herein, we present the first metabolomics and energetic profiling of norovirus-infected cells, which revealed increases in glycolysis, OXPHOS, and the pentose phosphate pathway (PPP) during murine norovirus (MNV) infection.
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