Publications by authors named "Jacob A Tickner"
Article Synopsis
- The study highlights the emergence of the M1UK variant of Streptococcus pyogenes as a significant global health threat, differing from the original M1global genotype by 27 SNPs and showing increased virulence through speA superantigen expression.
- Researchers developed a rapid allele-specific real-time PCR assay to detect M1UK strains and used whole-genome sequencing on 51 clinical isolates to assess the distribution of various emm (sub)types, finding M1UK dominant among the invasive and non-invasive strains.
- The findings confirm the ongoing presence of M1UK strains in Queensland, Australia, and suggest that the assay can be effectively used for enhanced surveillance of this particular pathogen.
Background: Mycoplasma genitalium infection is a sexually transmitted infection that has rapidly become resistant to mainstay treatments. While individualized treatment approaches have been recommended and adopted for macrolides, individualized therapy for fluoroquinolones has not yet been explored, due to a lack of commercial molecular assays and a lack of confidence in specific mutations associated with resistance. In another recent study, we defined a clear role and diagnostic utility in focusing on the absence of resistance mutations to inform microbial cure with fluoroquinolone antimicrobials.
View Article and Find Full Text PDFThe role of extracellular vesicles (EV) in carcinogenesis has become the focus of much research. These microscopic messengers have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissues, EVs are able to generate a pro-tumor environment that is essential for tumorigenesis.
View Article and Find Full Text PDFThe role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissue, exosomes are able to generate a pro-tumor environment that is essential for carcinogenesis.
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