Publications by authors named "Jacob A Noeker"
Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is modeled by mice.
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- E-cigarettes are marketed as a healthier option compared to traditional tobacco, but their health impacts, particularly on bone health, are still not fully understood.
- The study investigated how various flavored e-liquids affect human bone-forming cells (osteoblasts), finding that all e-liquids reduced cell viability in a dose-dependent manner, especially those flavored with cinnamon.
- Results indicated that certain flavors, like coffee and fruit, can actually increase collagen production in osteoblasts, suggesting that flavored e-liquids could have unique effects on bone health independent of nicotine.
The heavy metal cadmium is a widespread environmental contaminant that has gained public attention due to the global increase in cadmium-containing electronic waste. Human exposure to cadmium is linked to the pathogenesis of osteoporosis. We previously reported cadmium induces apoptosis and decreases alkaline phosphatase mRNA expression via extracellular signal-regulated protein kinase (ERK) activation in Saos-2 bone-forming osteoblasts.
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